INTERNATIONAL WORKSHOP ON HUMAN CHROMOSOME 5

5号染色体占人类基因组的5%或约150 DNA的兆碱基。仅仅在过去的两年里， 映射到染色体5，包括基因负责：脊髓 肌肉萎缩（SMA）、特雷彻·柯林斯综合征（TCOF 1）、畸形性 发育不良（DTD）、过度兴奋（STHE）、常染色体显性肢带型 肌萎缩症（LGMD 1）和迟发性遗传性耳聋。因此 在这些疾病基因相关的研究中， 以前对5号染色体兴趣不大，现在正在积极研究 对这条染色体进行遗传和物理绘图研究。此外，本发明还提供了一种方法， 5号染色体包含了大量的基因， 因子、生长因子受体和激素/神经递质受体， 这促使这些地区的调查人员开发了一种特殊的 对染色体的兴趣有这么多的团体对特定的 5号染色体的区域，大量的物理和遗传连锁 不同的实验室正在绘制地图。 研讨会的目的是整合来自不同群体的数据， 由一个或多个团体开发的可能对其他团体有用的资源 并绘制出一致的物理和遗传图谱。的结果 研讨会将确定哪些位点可以明确地在两个 地图类型，确定不同群体之间的重叠区域， 指出需要解决的不一致区域。在 此外，一份详尽的克隆坐标清单， YAC文库和5号染色体流式分选的粘粒文库将在 编译，以便每个人都可以访问所有已知的克隆片段， 5号染色体。会议将包括对当前状态的总结 5号染色体的物理和连锁图 委员会联合主席，各参与实验室的简短报告 （包括所有数据的讲义），并将以一个激烈的 为期半天的工作会议，在会议上，个人将分为 更小的群体，以产生不同的共识物理和遗传图谱 解决不同国家和地区制作的地图之间的差异， 最终结果将是一致的物理和连锁图谱， 跨越5号染色体。

Chromosome 5 represents 5% of the human genome or approximately 150 megabases of DNA. In just the past two years, six disease genes have been mapped to chromosome 5 including the genes responsible for: spinal muscular atrophy (SMA), Treacher Collins syndrome (TCOF1), diastrophic dysplasia (DTD), hyperekplexia (STHE), autosomal dominant limb-girdle muscular atrophy (LGMD1) and late onset hereditary deafness. As a result of these disease gene related studies, a number of investigators who previously had little interest in chromosome 5 are now actively pursuing genetic and physical mapping studies on this chromosome. In addition, chromosome 5 contains an extraordinary number of genes encoding growth factors, growth factor receptors and hormone/neurotransmitter receptors, which has prompted investigators in these areas to develop a particular interest in chromosomes. With so many groups interested in specific regions of chromosome 5, a large amount of physical and genetic linkage mapping is being done by different laboratories.The purpose of this workshop is to consolidate the data from different groups, identify resources developed by one or more groups which may be useful to others and to produce consensus physical and genetic maps. The results of the workshops will establish which loci can be unequivocally ordered on both types of maps, identify regions of overlap between different groups and point out regions of inconsistency which need to be addressed. In addition, an exhaustive list of clone coordinates for publicly available YAC libraries and the chromosome 5 flow-sorted cosmid library will be compiled so that everyone will have access to all known cloned segments of chromosome 5. The meeting will consist of a summary of the current state of the physical and linkage maps of chromosome 5 by the chromosome 5 committee co-chairs, short reports by each participating laboratory (including handouts of all data presented) and will finish with an intense half-day working session in which individuals will break down into smaller groups to produce consensus physical and genetic maps of different regions and to resolve discrepancies in maps produced by different groups.The end result will be consensus physical and linkage maps which span chromosome 5.