CHROMATIN AND TRANSCRIPTION--FASEB SUMMER RESEARCH CONF.

染色质和转录——FASEB 夏季研究会议。

• 批准号: 3435201
• 负责人: Daniel E. Gottschling
• 金额: $ 0.5万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-06-01 至 1994-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3435201
• 关键词: chromatin; chromosomes; developmental genetics; genetic transcription; health science research; meeting /conference /symposium; nucleic acid structure; transcription factor; travel

A considerable research effort in the past decade has characterized numerous transcription factors and dissected the regulatory elements of many genes. In spite of this success we know little concerning how these factors and elements function within the nucleus. The compaction of DNA into chromatin and chromosomes poses many problems, and yet potentially provides many insights into transcriptional regulation. Methodological breakthroughs are leading to substantial progress in understanding how nuclear architecture and chromatin structure is shaped in vivo. These results suggest that factors, DNA and structural proteins interact to facilitate the regulation of genes. The purpose of the proposed meeting is to critically analyze our current understanding of how nuclear organization contributes to gene regulation and to address the most fruitful avenues for further investigation. By bringing together the leading molecular geneticists, molecular biologists, biochemists and biophysicists in this rapidly developing field, the concepts and methodological approaches that are particularly successful can be rigorously discussed in an intensive and informal environment. A Major aim of such a conference is to serve as a catalyst for stimulating the interest of a wide audience of scientists who may already have the tools in hand to approach gene regulation in the context of nuclear structure, with a focus upon those young investigators who are yet to initiate a major area of independent research.

在过去十年中，一项相当大的研究工作表明， 许多转录因子和解剖的调控元件， 许多基因。 尽管取得了成功，但我们对这些人如何做到这一点知之甚少。 这些因素和元素在细胞核内起作用。 DNA的压缩 染色质和染色体中的许多问题，但潜在的 提供了许多关于转录调控的见解。 方法学 突破性的进展使我们更好地理解 核结构和染色质结构在体内形成。 这些 结果表明，因子、DNA和结构蛋白相互作用， 促进基因的调节。 拟议会议的目的 是批判性地分析我们目前对核武器 组织有助于基因调控和解决最 为进一步调查提供了富有成效的途径。 通过汇集 领先的分子遗传学家、分子生物学家、生物化学家和 在这一迅速发展的领域，生物药理学的概念和 特别成功的方法学途径， 在紧张和非正式的环境中进行严格的讨论。 一个主要 这样一个会议的目的是作为一种催化剂， 可能已经拥有工具的广大科学家的兴趣 为了在核结构的背景下接近基因调控， 重点关注那些尚未开始研究的年轻研究人员， 独立研究的主要领域。