ENHANCEMENT OF LUBRICATION FOR ARTIFICIAL CARTILAGE

增强人造软骨的润滑

• 批准号: 2080792
• 负责人: Martine LaBerge
• 金额: $ 10.74万
• 依托单位: CLEMSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-05-01 至 1995-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2080792
• 关键词: arthroplasty; biomaterial interface interaction; biomechanics; cartilage transplantation; elastomers; mathematical model; polymers; surface property

DESCRIPTION: (Adapted from investigator's abstract) Many osteo-articular diseases involve the degeneration of only one side of an articular joint such as chondromalacia, and avascular necrosis. In order to improve the parient's condition, this articular surface or articular defect may be replaced by an implant which functions as an artificial cartilage. Unfortunately, this articulation of an inert material with relatively healthy cartilage may cause problems on a long term basis, such as cartilage wear leading to the recurrence of pain. It is postulated that this surgical technique could be improved through providing an intrinsic boundary lubrication mechanism attached to the surface of the artificial material. The long term objective of the project is to determine if phosphatidylcholined (predominant phospholipids in synovial fluid) ionically attached to an elastomeric surface can be used to reduce friction and wear of cartilage in hemiarthroplasty conditions or for the repair of osteochondral defects. The specific aims of this study are: 1:To measure the coefficient of friction of articular cartilage bearing against a chemically treated elastomeric surface under simulated physiological conditions. 2:To characterize the role of phospholipid coating and its thickness in synovial joint lubrication for the contact cartilage/elastomer in vitro. 3:To develop a mathematical model of the elastic contact between cartilage, phospholipid layer, and elastomer to predict the behavior of the surfactant in biomechanical conditions. It is proposed to etch the surface of an elastomeric material to render it negatively charged. The bonding of a layer of phosphatidylcholine on this surface as a surfactant will reduce the coefficient of friction between elastomer and cartilage. An in vitro tribological study (simulating physiological conditions) of the contact elastomer-cartilage will enable the evaluation of the effect of surface treatment on the reduction of the coefficient of friction. These tests will be also performed with untreated elastomeric surface. Solutions of phospholipids and hyaluronic acid will be used as lubricants. Fatigue tests will be performed to characterize the adhesion of the phospholipidic coating onto the elastomer. After testing both cartilage and elastomer structure will be characterized.

描述：(改编自调查人员摘要)许多骨关节 疾病只涉及关节的一侧退变。 如软骨软化症和股骨头缺血性坏死。为了改善这一状况 患者的情况下，这种关节表面或关节缺陷可能是 取而代之的是作为人造软骨的植入物。 不幸的是，这种惰性物质与相对 健康的软骨可能会导致长期的问题，例如 软骨磨损会导致疼痛复发。据推测， 这种外科技术可以通过提供一种内在的 附着在人工关节表面的边界润滑机制 材料。该项目的长期目标是确定 磷脂酰胆碱(滑液中的主要磷脂) 离子连接到弹性体表面可以用来减少 半关节置换术中软骨的摩擦和磨损 骨软骨缺损的修复。这项研究的具体目的是： 1：测量关节软骨承载的摩擦系数 在模拟条件下对化学处理的弹性体表面进行撞击 生理条件。2：表征磷脂的作用 滑膜接触润滑中的涂层及其厚度 软骨/弹性体的体外实验。3：建立一个数学模型 软骨、磷脂层和弹性体之间的弹性接触 预测表面活性物质在生物力学条件下的行为。 有人建议在弹性材料的表面进行蚀刻以使其呈现出来。 带负电荷。在此表面结合一层磷脂酰胆碱 表面作为表面活性剂会降低摩擦系数 弹性体和软骨。 一种体外摩擦学研究(模拟生理条件) 接触弹性体-软骨将使效果评估成为可能。 表面处理对降低摩擦系数的作用。 这些测试也将在未经处理的弹性体表面上进行。 磷脂和透明质酸溶液将用作润滑剂。 将进行疲劳测试，以表征材料的粘附性 弹性体上的磷脂涂层。在测试了两个软骨之后 并对弹性体结构进行了表征。

项目成果

Evaluation of the frictional properties of an elastomer with enhanced lipid-adsorbing ability.

评估具有增强脂质吸附能力的弹性体的摩擦性能。

• DOI: 10.1243/0954411971534485
• 发表时间: 1997
• 期刊: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
• 作者: Williams3rd,PF;Iwasaki,Y;Ishihara,K;Powell,GL;Gilbert,JA;Nakabayashi,N;LaBerge,M
• 通讯作者: LaBerge,M

Fabrication and characterization of dipalmitoylphosphatidylcholine-attracting elastomeric material for joint replacements.

用于关节置换的二棕榈酰磷脂酰胆碱吸引弹性体材料的制造和表征。

• DOI: 10.1016/0142-9612(95)93582-x
• 发表时间: 1995
• 期刊: Biomaterials
• 影响因子: 14
• 作者: Williams3rd,PF;Powell,GL;Love,B;Ishihara,K;Nakabayashi,N;Johnson,R;LaBerge,M
• 通讯作者: LaBerge,M

Sliding friction analysis of phosphatidylcholine as a boundary lubricant for articular cartilage.

磷脂酰胆碱作为关节软骨边界润滑剂的滑动摩擦分析。

• DOI: 10.1243/pime_proc_1993_207_268_02
• 发表时间: 1993
• 期刊: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
• 作者: Williams3rd,PF;Powell,GL;LaBerge,M
• 通讯作者: LaBerge,M