MOLECULAR AND GENETIC BASIS FOR CELL PROLIFERATION

我请求1991年戈登研究会议的部分支持， 细胞增殖的分子和遗传基础。 本次会议， 在交替的几年里，重点是细胞内的事件， 在动物细胞周期的四个阶段，有丝分裂，G1，S 和G2。 生长因子和癌基因领域的最新进展是 在本会议内讨论;然而，本会议并不受 生长因子/癌基因主题，这是其他研究的核心， 国家会议。 1991年的会议将更加强调复制DNA 比过去几年更有综合性。 会议还将强调 细胞周期中G2-a期的分子生物学， 在向纯合性转化和肿瘤暴露方面有显著的作用 抑制基因 关于肿瘤抑制基因功能的新数据， 因为在细胞周期的G1/S期边界处的Rb将被突出显示。 会议的全部范围概括在以下清单中， 九届会议的标题： 1.生长因子受体 6.G2阶段：DNA纯化 2.信号转导 维修和转换为 纯合子 3.立即诱导 7.肌萎缩症的分子生物学 早期基因 8.肾母细胞瘤与P53 4. G1/S相边界 9.细胞周期与发育 29名与会者将在这次会议上提交研究论文。 他们将成为各自领域的顶尖科学家。 的 会议的独特之处在于，它汇集了从事这两方面工作的科学家 细胞复制的调控和结构方面。 这 并置促进了对动物研究的创造性新方法 细胞周期，因为它涉及过度增殖性疾病， 和动脉粥样硬化。

I request partial support of the 1991 Gordon Research Conference on "The Molecular and Genetic Basis for Cell Proliferation". This Conference, held in alternate years, focuses upon intracellular events which regulate movement through the four stages in the animal cell cycle, mitosis, G1, S and G2. Current developments in the growth factor and oncogene fields are addressed within this Conference; however, the Conference is not dominated by the growth factor/oncogene theme which is the centerpiece of other national meetings. The 1991 Conference will place greater emphasis on replicative DNA synthesis than it has in years past. The Conference will also highlight the molecular biology of G2-a phase in the cell cycle which may figure prominently in conversion to homozygosity and the unmasking of tumor suppressor genes. New data on the function of tumor suppressor genes such as rb at the G1/S-phase boundary of the cell cycle will be highlighted. The full scope of the conference is summarized in the following list of titles for the nine sessions: 1. Growth Factor Receptors 6.G2 Phase: DNA Recombination 2. Signal Transduction Repair and Conversion to Homozygosity 3. Induction of Immediate 7. Molecular Biology of Mytosis Early Genes 8. Wilms Tumor and P53 4. The G1/S-phase Boundary 9. Cell Cycle and Development Twenty-nine participants will present research papers at this Conference. These will be leading scientists in their respective fields. The Conference is unique in that it brings together scientists working on both the regulatory and the structural facets of cell replication. This juxtaposition promotes creative new approaches to research on the animal cell cycle as it relates to hyper proliferative disorders such as cancer and atherosclerosis.