SEXUAL PREFERENCE IN MICE

小鼠的性偏好

• 批准号: 3439533
• 负责人: JOHN G NYBY
• 金额: $ 8.1万
• 依托单位: LEHIGH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-08-01 至 1990-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3439533
• 关键词: androgens; animal age group; biological models; estrogens; gender difference; hormone regulation /control mechanism; pheromone; preference; sex behavior; sex hormones; testosterone; urine

The performance of sexual behavior in mammals seems to be regulated by two independent motivational substrates, arousability and orientation. Arousability determines the threshold for sex behavior, while orientation influences the choice of the sex partner's gender. While a great deal is known about the mechanisms that regulate arousability, much less is known about the mechanisms that contribute to orientation. A major reason for our ignorance of the causes of sexual orientation is that most animal models that have been described for this phenomenon have been rejected as unsatisfactory. The proposed research represents an attempt to explore some biological factors which may affect a newly described, more satisfactory animal model. The animal model for sexual orientation which will be explored involves the attraction that male and female mice (Mus musculus) exhibit for conspecific urinary odors. The proposed research will examine whether the sexual dimorphism in mouse urinary preferences is organized by the neonatal effects of gonadal hormones. A variety of different strategies will be employed, including neonatal and adult gonadectomy, infant and adult hormone replacement, neonatal blockage of androgen and estrogen receptors, and neonatal blockage of the conversion of testosterone to either estrogens or 5-alpha reduced androgens. In addition, an attempt will be made to map the neonatal sensitive period for hormonal action. This research has a high probability of providing important information about the physiological substrates of mouse sexual orientation.

哺乳动物的性行为表现似乎 由两个独立的动机基质调节， 可唤醒性和定向性。 可唤醒性决定了 性行为的阈值，而取向影响选择 性伴侣的性别。 虽然人们对这一点了解很多， 调节唤醒性的机制，对它的了解要少得多。 有助于定向的机制。 一个主要原因 因为我们对性取向的原因一无所知， 已经描述了这种现象的动物模型， 因不满意而被拒绝。 拟议研究 代表了一种探索生物因素的尝试， 可能影响新描述的更令人满意的动物模型。 性取向的动物模型， 包括雄性和雌性老鼠（小家鼠）的吸引力， 尿液气味的证据 拟议的研究将 检查小鼠尿中是否存在性二型 偏好是由性腺的新生效应组织的， 荷尔蒙 将采用各种不同的策略， 包括新生儿和成人性腺切除术、婴儿和成人 激素替代，新生儿雄激素阻断， 雌激素受体，和新生儿阻断的转换， 睾酮与雌激素或5-α还原型雄激素的比例。 在 此外，还将尝试绘制新生儿敏感区域图 荷尔蒙作用的时期。 这项研究有很大的可能性 提供了重要的生理信息， 小鼠性取向的基质。