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Reflexive Testosterone Release in Males

男性反射性睾酮释放

基本信息

批准号：
6665992
负责人：
JOHN G NYBY
金额：
$ 20.09万
依托单位：
LEHIGH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-08-15 至 2008-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6665992
关键词：
analgesics arousal biochemical evolution hormone metabolism hormone regulation /control mechanism laboratory rat male reinforcer sex behavior testosterone tranquilizer

项目摘要

DESCRIPTION (provided by applicant): Many mammals, including humans, exhibit reflexive testosterone release during sexual encounters. However, the function of this release is unclear. This proposal is based upon the hypothesis that reflexive testosterone release has immediate effects upon the male's physiology and behavior to better prepare him to cope with the reproductive situation in which he finds himself. Scattered supportive evidence in the scientific literature indicates that testosterone treatment in rodents has quick effects in promoting male sexual reflexes and is experienced by male rodents as being rewarding, anxiolytic, and analgesic, all of which could potentially facilitate the expression of reproductive behavior. The proposed studies will test that hypothesis more explicitly by examining whether several different endpoints (reward and anxiety) in normal male mice are affected by the quick actions of testosterone when it is administered in such a way as to mimic naturally occurring testosterone release. Several questions will be addressed including 1) How does one best mimic the pulsatile testosterone release of gonadally intact males? 2) Is the reflexive release of testosterone experienced as rewarding in mice? 3) What level of sexual arousal is necessary before a male muse shows reflexive testosterone release? 4) Does the reflexive release of testosterone exert different effects upon physiology and behavior than spontaneous testosterone release in mice? The proposed research is basic research designed to better understand the role that reflexive testosterone release plays in normal male-typical behaviors. However, since reflexive testosterone release is evolutionarily conserved, we believe our results also will have relevance for understanding the same processes in other mammalian species including humans. Moreover, we believe that our results may also be directly relevant for understanding the seemingly addictive (i.e., rewarding) properties of anabolic steroid use in humans as well.

描述（由申请人提供）：许多哺乳动物，包括人类，在性接触中表现出反射性睾酮释放。然而，该版本的功能尚不清楚。这个建议是基于这样一个假设，即反射性的睾丸激素释放对男性的生理和行为有直接的影响，使他更好地准备好应对他所处的生殖环境。科学文献中零散的支持性证据表明，在啮齿类动物中，睾酮治疗在促进雄性性反射方面具有快速效果，并且在雄性啮齿类动物中具有奖励、焦虑和镇痛作用，所有这些都可能促进生殖行为的表达。拟议的研究将通过检查正常雄性小鼠的几个不同终点（奖励和焦虑）是否受到睾丸激素的快速作用的影响来更明确地验证这一假设，当睾丸激素以模仿自然发生的睾丸激素释放的方式施用时。几个问题将被解决，包括1)如何最好地模拟性腺完整的男性的搏动性睾酮释放？2)在小鼠中，反射性释放睾丸激素是有益的吗？3)在男性缪斯表现出反射性睾酮释放之前，什么程度的性唤起是必要的？4)睾酮的反射性释放对小鼠生理和行为的影响是否与自发性睾酮释放不同？这项提议的研究是基础研究，旨在更好地理解反射性睾酮释放在正常男性典型行为中所起的作用。然而，由于反射性睾酮释放在进化上是保守的，我们相信我们的结果也将有助于理解包括人类在内的其他哺乳动物的相同过程。此外，我们相信我们的结果也可能与理解人类使用合成代谢类固醇的表面成瘾（即奖励）特性直接相关。