权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

ANXIOLYTIC EFFECT OF ALCOHOL IN CLINICALLY ANXIOUS WOMEN

酒精对临床焦虑女性的抗焦虑作用

基本信息

批准号：
3563736
负责人：
DANIEL R MCLEOD
金额：
$ 5.93万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1985
资助国家：
美国
起止时间：
1985-09-27 至 1988-08-31
项目状态：
已结题

项目摘要

The etiology of alcoholism involves both familial and nonfamilial factors. Identification of nonfamilial determinants of alcoholism, which are amenable to modification, can lead to the development of effective interventions and appropriate preventive measures can be taken. If anxiety reduction following alcohol is one such factor, then clinically anxious patients, for whom anxiety is a way of life, may be a high risk for alcohol abuse. The acute effects of ethanol in such a population will be assessed in the present study. Specifically, the anxiolytic effects of alcohol will be assessed in women with generalized anxiety disorder by measuring the effects of two doses of ethanol on the psychological and somatic symptoms of anxiety. A 3 x 2 factorial design will be used (dose x phase of menstrual cycle) with repeated measures on one factor (phase of menstrual cycle). Subjective ratings, electroencephalographic activity, electrodermal activity, cardiovascular activity, including heart interbeat interval, blood pressure, and finger temperature, frontalis and gastrocnemius electromyographic activity, respiration, and cognitive/psychomotor performance will be measured in three groups of patients, one receiving placebo, one receiving 0.5 g/kg and one receiving 1.0 g/kg ethanol. Subjective and psychophysiological responses to two types of stressors, one requiring concentrated attention (Concentration Task) and the other requiring little cognitive effort (Risk-Taking Task), will be assessed during two phases of the menstrual cycle: the premenstrual and follicular phases. Results of the study will provide a comprehensive profile of the subjective and psychophysiological effects of ethanol in a clinically anxious population during two phases of the menstrual cycle. A reduction in anxiety by alcohol would permit the identification of a population at risk for alcohol abuse and would provide information as to whether this population is more vulnerable to alcohol abuse during the premenstrual than during the follicular phase of the menstrual cycle.

酒精中毒的病因包括家族性和非家族性因素。确定酗酒的非家族性决定因素，可以进行修改，可以导致有效的发展，可以采取干预和适当的预防措施。如果焦虑酒精后减少就是这样一个因素，然后临床焦虑对于那些焦虑是一种生活方式的患者来说，虐待将评估乙醇对此类人群的急性影响在本研究中。具体来说，酒精的抗焦虑作用将通过测量广泛性焦虑症患者的两种剂量乙醇对精神和躯体症状的影响焦虑将使用3 x 2析因设计（剂量x阶段）。月经周期），对一个因素（月经期）进行重复测量循环）。主观评分脑电图活动，皮电活动、心血管活动，包括心脏间跳间隔，血压，手指温度，额肌和腓肠肌肌电活动、呼吸和认知/心理表现将在三组中进行测量，患者，1例接受安慰剂，1例接受0.5 g/kg，1例接受 1.0 g/kg乙醇。对两种疾病的主观和心理生理反应压力源的类型，一个需要集中注意力（集中任务）和另一个几乎不需要认知努力（冒险任务），将在月经周期的两个阶段进行评估：经前期和卵泡期。研究结果将提供的主观和心理生理影响的全面概况乙醇在临床焦虑人群中的两个阶段，月经周期通过酒精减少焦虑将允许确定有酗酒风险的人群，关于这一人群是否更容易酗酒的信息在月经前比在卵泡期的滥用月经周期