FAMILY HISTORY OF ALCOHOLISM AND PREMENSTRUAL SYMPTOMS

家族酗酒史和经前症状

• 批准号: 2045069
• 负责人: DANIEL R MCLEOD
• 金额: $ 20.15万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-01 至 1996-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2045069
• 关键词: alcoholic beverage consumption; alcoholism /alcohol abuse; anxiety; depression; ethanol; family genetics; family structure /dynamics; female; human subject; interview; male; menstrual cycle; parents; personality; premenstrual syndrome; psychophysiology

Two important areas of study that have received little attention involve 1) women with a family history of alcoholism and 2) relationships between alcohol-related problems and premenstrual symptoms. However, retrospectively obtained pilot data from our laboratory and OB/GYN clinic suggest a strong relationship between paternal-side family history of alcoholism and increased premenstrual alcohol consumption in women with PMS and alcoholic women tend to report increased alcohol consumption during the premenstruum. The purpose of the present series of studies is to begin a comprehensive program of research to examine the differences between m" with PMS who do (Pa+) and do not (Pa-) have a paternal-side family history of alcoholism. Study 1: To confirm the results of our earlier retrospective study, prospective daily records of symptoms and alcohol consumption patterns will be kept for 3 menstrual cycles and premenstrual symptom severity and alcohol consumption patterns across the cycle will be in Pa+ and Pa- patients. Study 2: Pa+ and Pa- patients will be compared in detail during the premenstrual and follicular phases of the cycle on standardized measures of anxiety and depression, and on several physiological correlates of anxiety. Study 3: Cloninger and colleagues have postulated that women with an anxious, type 1 personality will tend to show a maternal-side, but not a paternal-side, family history of alcoholism. However, our pilot data suggest a paternal-side family history of alcoholism in women who present clinically with type 1 features. Cloninger's Tridimensional Personality Questionnaire will be administered to determine whether Pa+ patients possess a type 1 or type 2 personality profile, and the profiles of the Pa+ and Pa- groups will be compared. Study 4: Patients in our pilot study reported drinking premenstrually to reduce tension, suggesting a family history x premenstrual tension-reduction interaction. The anxiolytic and physiological effects of alcohol will be compared in Pa+ and Pa- patients. Four laboratory sessions will be conducted over two menstrual cycles. In a crossover design, Pa+ and Pa- patients will be given 0.5 g/kg ethanol and placebo during both the premenstrual and follicular phases of the menstrual cycle. The results of these studies will provide a good first step toward an understanding of the relationships between family history of alcoholism and postnatal influences on patterns of alcohol consumption and on the psychological and physiological characteristics of women with PMS.

两个重要的研究领域，很少受到关注，包括1） 有酗酒家族史的女性; 2） 酒精相关问题和经前症状。 然而，在这方面， 回顾性地从我们的实验室和妇产科诊所获得了初步数据 表明父系家族史与 经前综合征妇女的酗酒和经前饮酒增加 而酗酒的女性往往会报告说， precedium. 本系列研究的目的是开始一项 一项全面的研究计划，以研究m”之间的差异 有（Pa+）和无（Pa-）父系家族史的PMS患者 酒精中毒 研究1：为了证实我们早期的结果， 回顾性研究，前瞻性每日记录症状和酒精 消费模式将保持3个月经周期和月经前 整个周期的症状严重程度和酒精消费模式将是 Pa+和Pa-患者。 研究2：将比较Pa+和Pa-患者， 在月经前期和卵泡期的细节周期上 焦虑和抑郁的标准化措施，并在几个 焦虑的生理相关性。 研究3：Cloninger及其同事 我曾假设，具有焦虑的1型人格的女性往往会 显示出母亲一方，而不是父亲一方， 酒精中毒 然而，我们的试验数据表明， 临床表现为1型特征的女性中的酒精中毒。 将进行Cloninger三维人格问卷调查 确定Pa+患者是否具有1型或2型人格 将比较Pa+和Pa-组的曲线。 研究4：我们的初步研究中的患者报告婚前饮酒， 减少紧张，提示有家族史x经前 张力降低相互作用。 抗焦虑和生理作用 将在Pa+和Pa-患者中比较酒精。 四次实验室会议 将在两个月经周期内进行。 在交叉设计中，Pa+ 和Pa-患者将在两次治疗期间给予0.5 g/kg乙醇和安慰剂。 月经周期的经前期和卵泡期。 的结果 这些研究将为理解 酒精中毒家族史与产后影响的关系 酒精消费模式以及心理和 PMS女性的生理特征。