ECOLOGY AND CONTROL OF ARBOVIRUSES

这个项目的长期目标是获得足够的知识 虫媒病毒生态学的研究，以制定有效的战略 控制那些与公共卫生和兽医有关的虫媒病毒病 在北美的重要性。目前提出了六个方面的研究 为了达到这一目标：实验室研究以阐明内在的 控制选定蚊子能力的因素和机制 传播引起流行病的虫媒病毒的物种；受控实验室 温度对外在孵化影响的研究 蚊子媒介中的虫媒病毒和平行的现场研究 评估温度作为影响环境因素的作用 西部马脑脊髓炎的季节和年度分布 圣路易斯脑炎病毒；深入的野外生态研究 农村农业和河岸沼泽地新城疫病毒及其媒介 加利福尼亚州克恩县的栖息地确定病毒的基本疫源地 从这种疫源地传播和传播模式；研究 解释6种地方病越冬的替代假说 克恩县节肢动物媒介和脊椎动物宿主中的虫媒病毒， 开发统计-流行病学模型，将 综合控制蚊子数量增长的变量和 相关的虫媒病毒传播周期，包括 控制媒介种群的替代战略；并总结 过去40年的研究成就，以 《中国节肢动物传播病毒的流行病学》专著 加利福尼亚，1943-1984年。

The long-term objective of this project is to gain a sufficient knowledge of the ecology of arboviruses for development of effective strategies to control those arboviral diseases that are of public health and veterinary importance in North America. Six areas of research are proposed currently to attain this objective: laboratory studies to elucidate instrinsic factors and mechanisms that control the competence of selected mosquito species to vector arboviruses that cause epidemics; controlled laboratory studies to determine the effect of temperature on the extrinsic incubation of arboviruses in their mosquito vectors and parallel field studies to evaluate the role of temperature as an environmental factor that influences the seasonal and yearly patterns of western equine encephalomyelitis and St. Louis encephalitis viruses; in-depth field studies on the ecology of WEE virus and its vectors in rural agricultural and riparian/marshland habitats in Kern County, California to identify basic foci of viral transmission and patterns of dissemination from such foci; study of alternative hypotheses to explain the overwintering of 6 enzootic arboviruses in their arthropod vectors and vertebrate hosts in Kern County, California; to develop statistical-epidemiological models that will integrate the variables that control mosquito population growth and associated arboviral transmission cycles including the impact of alternative strategies for control of vector populations; and to summarize research accomplishments during the past 40 years in the form of a monograph on "The Epidemiology of the Arthropod-borne Viruses in California, 1943-1984."