ECOLOGY AND CONTROL OF ARBOVIRUSES

虫媒病毒的生态学和控制

• 批准号: 3444414
• 负责人: JAMES L HARDY
• 金额: $ 56.63万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 1974
• 资助国家: 美国
• 起止时间: 1974-09-01 至 1990-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3444414
• 关键词: Togaviridae; communicable disease control; communicable disease transmission; ecology; environmental health; epidemiology; temperature; virus genetics

The long-term objective of this project is to gain a sufficient knowledge of the ecology of arboviruses for development of effective strategies to control those arboviral diseases that are of public health and veterinary importance in North America. Six areas of research are proposed currently to attain this objective: laboratory studies to elucidate instrinsic factors and mechanisms that control the competence of selected mosquito species to vector arboviruses that cause epidemics; controlled laboratory studies to determine the effect of temperature on the extrinsic incubation of arboviruses in their mosquito vectors and parallel field studies to evaluate the role of temperature as an environmental factor that influences the seasonal and yearly patterns of western equine encephalomyelitis and St. Louis encephalitis viruses; in-depth field studies on the ecology of WEE virus and its vectors in rural agricultural and riparian/marshland habitats in Kern County, California to identify basic foci of viral transmission and patterns of dissemination from such foci; study of alternative hypotheses to explain the overwintering of 6 enzootic arboviruses in their arthropod vectors and vertebrate hosts in Kern County, California; to develop statistical-epidemiological models that will integrate the variables that control mosquito population growth and associated arboviral transmission cycles including the impact of alternative strategies for control of vector populations; and to summarize research accomplishments during the past 40 years in the form of a monograph on "The Epidemiology of the Arthropod-borne Viruses in California, 1943-1984."

该项目的长期目标是获得足够的知识 虫媒病毒生态学的研究，以制定有效的策略 控制那些影响公共卫生和兽医的虫媒病毒疾病 在北美的重要性。 目前提出六个研究领域 为了实现这一目标：通过实验室研究来阐明内在的 控制选定蚊子能力的因素和机制 传播引起流行病的虫媒病毒的物种；受控实验室 研究确定温度对外部孵化的影响 蚊子媒介中的虫媒病毒和平行实地研究 评估温度作为影响环境因素的作用 西方马脑脊髓炎的季节性和年度模式 圣路易斯脑炎病毒；对生态学进行了深入的实地研究 农村农业和河岸/沼泽地中的 WEE 病毒及其载体 加利福尼亚州克恩县的栖息地以确定病毒的基本疫源地 这些焦点的传播和传播模式；研究 解释 6 种地方性动物越冬的替代假设 克恩县节肢动物载体和脊椎动物宿主中的虫媒病毒， 加利福尼亚州；开发统计流行病学模型 整合控制蚊子种群增长的变量 相关的虫媒病毒传播周期，包括影响 控制病媒种群的替代策略；并总结 过去40年的研究成果以 专着《节肢动物传播病毒的流行病学》 加利福尼亚州，1943 年至 1984 年。”