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ELASTIC PROPERTIES OF CANCELLOUS BONE

松质骨的弹性特性

基本信息

批准号：
3446366
负责人：
RICHARD B. ASHMAN
金额：
$ 4.03万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
1985
资助国家：
美国
起止时间：
1985-01-01 至 1987-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3446366
关键词：
biomedical equipment development bone bone density bone imaging /visualization /scanning bone prosthesis elasticity femur tibia

项目摘要

The long range objective of the proposed research is to map the elastic properties of the entire femur and tibia as a function of anatomical site. In previous work by the author, the elastic properties of the cortical portion of these were measured. To date, there exists no technique that can be used to obtain accurate values of the elastic properties from small specimens of cancellous bone. Hence, a large portion of the proposed work will be to develop such a technique. Having accurate values of the elastic properties as a function of position is a necessary prerequisite to the mechanical analysis of these load bearing bones; particularly in finite element analyses where accurate values of the elastic moduli, shear moduli, and Poisson's ratios are crucial to the design of improved hip and knee prosthetics. The specific aims of the proposed research are the develop an ultrasonic technique that can be used to measure the elastic properties of small specimens of cancellous bone. The proposed methodology is 1) to measure ultrasonic wave velocities over a range of frequencies from 50 kHz to 3 MHz, 2) to relate the velocities to elastic properties by appropriate continuum theories, 3) to measure material density, bulk density, and bone mineral content of the ultrasonic specimens, 4) to measure the elastic properties by mechanical methods on adjacent specimens, and 5) to correlate the ultrasonically measured elastic properties with the densities, mineral content, and mechanically measured elastic properties to evaluate the validity of the ultrasonic technique. Once the ultrasonic technique is developed, the elastic properties of the cancellous and cortical portions of both the femur and tibia will be mapped as a function of anatomical site.

所提出的研究的长期目标是绘制弹性作为解剖部位的函数的整个股骨和胫骨的特性。在作者以前的工作中，皮质的弹性特性其中一部分被测量。到目前为止，还没有技术，可以用来获得精确的值的弹性性能从小松质骨标本。因此，大部分拟议工作将是发展这样一种技术。具有精确的弹性值属性作为位置的函数是一个必要的先决条件，这些承重骨的力学分析;特别是在有限的单元分析，其中弹性模量，剪切模量，泊松比对改进的髋关节和膝关节的设计至关重要修复术. 提出的研究的具体目标是开发一种超声波技术，可用于测量弹性性能的小松质骨标本。拟议的方法是1）衡量超声波速度在50 kHz至3 kHz的频率范围内 MHz，2）通过适当的方法将速度与弹性特性联系起来连续体理论，3）测量材料密度、体积密度和骨密度矿物含量的超声波标本，4）测量弹性通过机械方法对相邻试样的性能，以及5）关联超声波测量的弹性特性与密度，矿物含量和机械测量的弹性性能，以评估超声波技术的有效性。一旦超声波技术松质骨和皮质骨部分的弹性将根据解剖部位绘制股骨和胫骨的解剖图。