ATLAS OF HUMAN BONE MECHANICAL PROPERTIES

人体骨骼力学特性图谱

• 批准号: 3157513
• 负责人: RICHARD B. ASHMAN
• 金额: $ 4.77万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-08-01 至 1990-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3157513
• 关键词: biological models; biomechanics; bone; bone density; bone imaging /visualization /scanning; bone metabolism disorder; bone prosthesis; disease /disorder model; elasticity; femur; human tissue; lumbosacral region; mandible /maxilla; model design /development; tibia

The overall objective of this work is produce an "Atlas of Human Bone Mechanical Properties". This atlas will document site specific, orthotropic elastic moduli, shear moduli, Poisson's ratios, densities, and structure of the cortical and cancellous regions of the femur, tibia, patella, humerus, radius, mandible, and thoracic and lumbar vertebrae. Elastic properties will be measured from several sites on each bone using a previously developed ultrasonic technique. Bones inlcuded in the study will be from four normal and four severely osteopenic human cadavers, with the determination of osteopenia will be made primarily by a transiliac biopsy. Such information is necessary and vital for the development of accurate finite element models of the skeletal system. Finite element modeling (FEM) is an important tool for the analysis of the mechanical response of biologic tissue to external forces. The versatility of FEM allows complicated geometry, as well as inhomogeneous and anisotropic material properties, to be easily incorporated into models of the skeletal system. With the increased availability and decreased price of more powerful computational hardware, combined with more sophisticated and less expensive software, very powerful modeling capabilities are becoming available to a large number of researchers for analyses of the effects of bone loss and prosthetic design.

这项工作的总体目标是编制一份《人类地图集 骨机械性能“。这本图集将记录网站 比、正交各向异性弹性模数、剪切模数、泊松比、 皮质区和松质区的密度和结构 股骨、胫骨、膝盖骨、肱骨、桡骨、下颌骨和胸骨 还有腰椎。弹性属性将从 使用先前开发的超声波在每根骨头上放置多个部位 技术。这项研究涉及的骨骼将来自四个正常 和四具严重的骨质疏松症的人类身体， 骨质疏松症的判定将主要由一名临床者进行。 活组织检查。 这些信息对于发展……是必要和至关重要的。 骨骼系统的精确有限元模型。有限 单元建模是分析金属材料力学性能的重要工具 生物组织对外力的机械反应。这个 有限元的多功能性允许复杂的几何图形，以及 非均质性和各向异性的材料属性，很容易 结合到骨骼系统的模型中。与 更高的可用性和更强大的价格 计算硬件，结合了更复杂和 更便宜的软件，非常强大的建模功能 可供大量研究人员进行分析 骨丢失和假体设计的影响。