OPTIMIZING PROTON THERAPY AT THE LBL MEDICAL ACCELERATOR

优化 LBL 医疗加速器的质子治疗

• 批准号: 3443673
• 负责人: JOSE ALONSO
• 金额: $ 57.64万
• 依托单位: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-30 至 1991-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3443673
• 关键词: biomagnetism measurement; building /facility design /renovation; clinical biomedical equipment; linear energy transfer; particle accelerators; proton beam; radiation therapy; radiation therapy dosage; radiobiology

LBL is proposing the construction of a dedicated biomedical center for intensive development of heavy charged-particle techniques for clinical use. We anticipate the construction to start within the next five years. This center will emphasize research with both protons and heavier ions. The rationale of a strong proton component of our program lies with intercomparison of low and high LET irradiations, and technology transfer of hardware and techniques developed for hospital-based clinical proton facilities to be built worldwide in the near future. Specifically we will: (1) Study the technical elements needed for designing an integrated, efficient, reliable and cost-effective proton treatment facility. Optimize accelerator designs, beam spreading techniques, gantries, control systems, and systems-integration. Analyze applicability of new ideas (e.g. rapid- pulsing systems) and emerging technologies (e.g. superconductivity). (2) Investigate ways to utilize the best characteristics of proton beams for treatment of human diseases. Study 3-D conformal treatment techniques, their expected clinical benefits, interfacing treatment plans with beam delivery system, and the merits of correlating multiple imaging modalities. Using the particle beams from the Vevalac and the LBL dynamic beam delivery system, assess the performance of a 3-dimensional conformal therapy delivery system. (3) Identify disease sites that would most benefit from proton therapy and develop protocols for these sites. Identify areas where radiobiological input is critical for aid in interpretation of clinical results. Select protocols for which equitable intercomparison can be made of the clinical benefits of protons (low LEt) and heavier ions (high LET). The results of the project will provide timely input to the scientific and medical community which is witnessing a significant transfer of advanced technology of heavy charged-particle medicine from research institutions into the clinical environment.

LBL正在提议建造一个专门的生物医学中心 用于临床的重带电粒子技术的深入发展 使用。我们预计这项工程将在未来五年内动工。 这个中心将重点研究质子和更重的离子。 我们计划中强质子组件的基本原理在于 低LET和高LET辐射的相互比较和技术转让 为基于医院的临床质子开发的硬件和技术 在不久的将来将在全球范围内建造的设施。具体来说，我们会： (1)研究设计一个完整的、 高效、可靠和具有成本效益的质子处理设施。优化 加速器设计、波束扩展技术、门架、控制系统、 和系统集成。分析新想法的适用性(例如，快速- (例如，脉冲系统)和新兴技术(例如超导)。(2) 研究如何利用质子束的最佳特性来 人类疾病的治疗。研究三维适形处理技术， 他们的预期临床益处，将治疗计划与BEAM对接 提供系统，以及多种成像方式相互关联的优点。 使用来自Vvalac和LBL动态束流的粒子束 系统，评估三维适形治疗的性能 传送系统。(3)找出最能从中获益的疾病地点 质子疗法，并为这些部位制定方案。确定以下领域 放射生物学输入对辅助临床解释至关重要 结果。选择可以进行公平相互比较的协议 质子(低LET)和重离子(高LET)的临床益处。 该项目的成果将为科学和技术人员提供及时的投入 医学界正在见证先进技术的重大转移 科研院所的重带电粒子药物技术 进入临床环境。