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ACID-ETCHING AND REMINERALIZATION OF ENAMEL CARIES

牙釉质龋齿的酸蚀和再矿化

基本信息

批准号：
3447071
负责人：
M J HICKS
金额：
$ 4.78万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
1983
资助国家：
美国
起止时间：
1983-08-01 至 1986-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3447071
关键词：
calcification dental caries electron microscopy phosphates tooth enamel topical fluoride therapy

项目摘要

Acid-etching of sound enamel results in an increase in the surface area and a more reactive surface. Since caries-like lesions possess an intact surface overlying the body of the lesion, it has been shown in pilot studies that typical etching patterns may be produced on the surfaces of caries-like lesions in vitro. The purpose of this study is to investigate the role of the acid-etch technique in caries formation, remineralization and progression. The techniques which will be used are qualitative and quantitative polarized light microscopy, scanning electron microscopy and chemical analyses for calcium, fluoride and phosphate. The study is divided into six, individual experiments. The first two will investigate the effects of acid-etching and sealing of sound enamel and caries-like lesions on lesion formation and progression. The next two experiments are directed toward evaluating the effect of the acid-etch technique used in conjunction with topical fluoride agents and calcifying fluids on lesion remineralization and progression. The morphology of crystals in sound enamel, etched enamel and caries-like lesions which have undergone various treatment regimens will be characterized in the fifth experiment. The final experiment will determine the concentrations of fluoride, calcium and phosphate present in surface zones from control, etched, remineralized and progressed caries-like lesions. These results will be compared with those obtained from sound enamel. The long range objective of this study is to develop a clinically applicable method to prevent caries formation and to remineralize existing lesions. The study will add to the basic knowledge regarding the acid-etch technique and the mechanisms of the carious process.

对完好的釉质进行酸蚀会导致表面积增加和一个更活跃的表面。由于龋齿样病变具有完整的表面覆盖在病变的身体上，它已经在飞行员中显示出来研究表明，典型的蚀刻图案可能产生在表面体外培养的龋样病变。这项研究的目的是调查酸蚀技术在龋病形成、再矿化中的作用和进步。将使用的技术是定性的和定量偏振光显微镜、扫描电子显微镜和钙、氟和磷的化学分析。这项研究是分为六个单独的实验。前两名将进行调查酸蚀封闭完好牙釉质和类龋病的效果观察病变对病变形成和发展的影响。接下来的两个实验是旨在评估酸蚀技术在联合外用氟化物和钙化液治疗皮损再矿化和进展。声音中晶体的形态牙釉质、酸蚀牙釉质和龋样病变经历了各种治疗方案将在第五个实验中进行描述。这个最终的实验将确定氟、钙和磷酸盐存在于表面区，来自对照，蚀刻，再矿化和进展性龋样病变。这些结果将与那些从完好的珐琅中提取。这项研究的长期目标是开发一种临床适用的预防龋病形成和治疗的方法使现有的病变重新矿化。这项研究将增加基础知识关于酸蚀技术和龋齿过程的机理。