THE EVALUATION OF LASER RADIATION ON ATHEROSCLEROSIS

本项目的目标是研究近期和长期的 激光辐射对动脉粥样硬化的有益或有害影响 在各种动物模型中的斑块和正常动脉。 做工作 首席研究员已经证明了使用激光的可行性 适用于光纤导管输送系统， 完全闭塞的人体尸检冠状动脉中的血管通道。 这是在血液或盐水介质下完成的。 此外，初步 在活体兔动脉粥样硬化模型中的工作继续证明 激光通过光纤系统传输的能力， 使动脉硬化阻塞的动脉再通。 激光损伤 斑块是一个干净的切口，在动脉的横截面上显示 斑块分为楔形段。 血管造影没有显示任何 激光照射家兔后远端血管中的碎片 动脉粥样硬化模型 为了进一步测试远端栓塞是否 在激光照射使用移植的人的狗模型后发生 将评价动脉粥样硬化冠状动脉。 过滤器将 放置在激光照射部位的远端以收集碎片。 在其他狗（与 正常动脉）进行长期研究，以评估 激光辐射对血管壁的有害影响，即，动脉瘤， 穿孔血栓形成一个多月 这些船只将 通过光学和电子显微镜技术进行研究。 额外 将进行实验以研究激光辐射的长期效应 动脉粥样硬化猴子的血管上。 这些船只将由 光学和电子显微镜。 在所有这些实验中， 将记录使用的激光能量（瓦特X时间），以确定 再通阻塞血管的最佳范围， 严重的血管壁损伤。

The objective of this project will be to study the immediate and long term beneficial or detrimental effects of laser radiation on the atheroslcerotic plaque and normal arteries in various animal models. Work done by the principal investigator has demonstrated the feasibility of using lasers adapted to a fiberoptic-catheter delivery system to re-establish new vascular channels in totally occluded human necropsy coronary arteries. This was accomplished under a blood or saline media. Also, preliminary work in the living rabbit atherosclerotic model continues to demonstrate the ability of the laser delivered through a fiberoptic system to recannalize arteries obstructed by atherosclerosis. The laser injury to plaque is a clean incision which on cross section of the artery shows the plaque divided into wedge-shaped segments. Angiography did not reveal any debris in the distal vessels following laser radiation of the rabbit atherosclerotic model. To further test whether distal embolization will occur following laser radiation a dog model using transplanted human atherosclerotic coronary arteries will be evaluated. Filters will be placed distally to the lased site to collect debris. In other dogs (with normal arteries) long term studies will be done to evaluate the potential detrimental effects of laser radiation on the vessel wall, i.e., aneurysm, perforation, thrombosis, over a one month period of time. The vessels will be studied by light and electron microscopic techniques. Additional experiments will be done to study the long term effects of laser radiation on vessels of atherosclerotic monkeys. These vessels will be evaluated by light and electron microscopy. In all of these experiments, the amount of laser energy (watts X time) used will be recorded in rder to determine optimal ranges to recannalize obstructed vessels without producing significant vessel wall damage.