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THE DEVELOPMENT OF SEXUAL BEHAVIOR: A MARSUPIAL MODEL

性行为的发展：有袋动物模型

基本信息

批准号：
3447919
负责人：
BARBARA H FADEM
金额：
$ 6.19万
依托单位：
UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
依托单位国家：
美国
项目类别：
财政年份：
1983
资助国家：
美国
起止时间：
1983-07-01 至 1987-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3447919
关键词：
behavior test blood chemistry cervical /vaginal smear estrogens estrus ethology gestational age growth /development hormone regulation /control mechanism male castration newborn animals ovariectomy progesterone psychophysiology radioimmunoassay sex behavior testosterone

项目摘要

The aim of the proposed studies is to clarify and quantify the effects of hormones during early life on the development of sexual and related behavior patterns in adult mammals. A marsupial mammal will be used since marsupials are born after brief gestation in a developmentally immature "fetal" condition. This marsupial model system permits direct visualization, quantification and manipulation of a mammalian prenatal (prenatal in a traditional mammalian model and postnatal in a marsupial mammalian model) environment. In the first group of studies, sexual and sexually dimorphic behavior patterns of a marsupial Monodelphis domestica, the gray short tailed opossum, will be correlated with changes in vaginal cytology and blood hormone levels. The hormone environment of neonates will then be quantified and manipulated and the effects of these manipulations on the previously quantified adult sexual and sexually dimorphic behavior patterns will be observed. Alterations in the prenatal environment of humans by hormones which affect adult behavior when applied prenatally such as progestins and corticosteroids and commonly used drugs such as alcohol, marijuana and diazepam are probable. Development of the unique marsupial model system proposed here will provide access to the heretofore inaccessable mammalian prenatal environment. As such, studies utilizing this system will further our knowledge about the effects of alterations in this environment on behavioral development in humans.

拟议研究的目的是澄清和量化的影响生命早期的激素对性及相关发育的影响成年哺乳动物的行为模式。自此以后将使用有袋哺乳动物有袋动物是在发育不成熟的情况下短暂妊娠后出生的 “胎儿”状态。该有袋动物模型系统允许直接哺乳动物产前的可视化、量化和操作（传统哺乳动物模型产前和有袋动物模型产后哺乳动物模型）环境。在第一组研究中，性和有袋动物 Monodelphis Domestica 的两性行为模式，灰色短尾负鼠，将与阴道的变化相关细胞学和血液激素水平。新生儿的激素环境然后将被量化和操纵，这些影响对先前量化的成人性行为和性行为的操纵将观察到二态行为模式。产前的改变人类环境中的激素会影响成人的行为产前使用，例如孕激素和皮质类固醇以及常用药物例如酒精、大麻和地西泮都是可能的。的发展这里提出的独特的有袋动物模型系统将提供访问迄今为止无法进入的哺乳动物产前环境。因此，研究利用该系统将进一步了解我们的影响这种环境的变化对人类行为发展的影响。