HEART RATE: LABORATORY REACTIVITY VS 24-HOUR VARIABILIT

心率：实验室反应性与 24 小时变异性

• 批准号: 3448673
• 负责人: MICHAEL H POLLAK
• 金额: $ 4.67万
• 依托单位: OSU CENTER FOR HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-07-01 至 1988-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3448673
• 关键词: behavioral medicine; cardiovascular stress test; cognition; coping; emotions; health; heart rate; human subject; male; oxygen consumption; performance; psychological stressor; psychomotor function; psychophysiology; stress

Current behavioral medicine research investigates the role of behavioral stress in the development of cardiovascular disease. Implicit in the rationale for much of this psychophysiological research are assumptions that individuals differ in characteristic reactivity to stressful situations at home and at work, and that these differences can be identified reliably by observing individual differences in cardiovascular reactivity to challenging laboratory tasks. The studies proposed here will test these assumptions by comparing individual differences in heart rate (HR) reactivity during challenging laboratory tasks and 24-hour ambulatory HR reactivity. The results should provide needed support for assumptions underlying important current psychophysiological research. Study 1 will examine the extent to which individual differences in HR reactivity to challenging laboratory tasks generalize to ambulatory HR during usual daily life. Each of 72 healthy young men will complete one laboratory session, during which they will sit quietly and then perform three challenging psychomotor or cognitive tasks; one 24-hour ambulatory recording day, during which HR and physical activity will be recorded minute-by-minute; and one graded maximal exercise test. The main hypotheses are that, compared to nonreactors, laboratory HR reactors will show greater mean and maximum daytime ambulatory HR and greater daytime ambulatory HR variability, but similar basal and minimum daytime ambulatory HR. Measures of functional aerobic capacity derived from the exercise test and of ambulatory physical activity and emotion will be used to investigate contributions of these factors to obtained relationships between laboratory and ambulatory HR. Study 2 examines the stability over one year of individual differences in laboratory HR reactivity and ambulatory HR variability. Study 2 subjects will be recruited one year later to repeat laboratory, ambulatory and exercise procedures identical to those of Study 1. Study 3 will test the hypotheses that ambulatory HR will be higher on days of relatively high life stress or challenge, and that this difference will be greatest for laboratory HR reactors compared to nonreactors. Each of 36 medical students will complete one laboratory session, two ambulatory recording days, and one graded exercise test. One ambulatory recording day will be a day of relatively low challenge (going to class); the other will be a day of relatively high challenge (patient care practicum). Laboratory, ambulatory, and exercise test procedures will be identical to those of Study l.

目前的行为医学研究调查行为的作用， 压力在心血管疾病发展中的作用。 中隐含 许多心理生理学研究的基本原理是假设 个体对压力的反应特征不同， 家庭和工作中的情况，这些差异可能是 通过观察心血管疾病的个体差异来可靠地识别 对具有挑战性的实验室任务的反应能力。 本文提出的研究将 通过比较心率的个体差异来验证这些假设 (HR)在挑战性实验室任务和24小时门诊期间的反应性 HR反应性。 结果应该为假设提供必要的支持 当前重要的心理生理学研究的基础。 研究1将检查HR的个体差异 对具有挑战性的实验室任务的反应性推广到动态HR 在日常生活中。 72名健康的年轻人每人将完成一项 实验室会议，在此期间，他们将安静地坐着，然后执行 三项具有挑战性的心理或认知任务;一项24小时门诊 记录日，在此期间将记录HR和体力活动 一分钟一分钟;和一个分级的最大运动试验。 主要 假设与非反应堆相比，实验室HR反应堆将 显示更大的平均和最大日间动态HR和更大的日间 动态HR变异性，但基础和最小日间动态相似 HR. 从运动试验中得出的功能性有氧能力的测量 和步行身体活动和情绪将被用来调查 这些因素对实验室之间关系的贡献 研究2检查了一年以上的稳定性， 实验室HR反应性和动态HR的个体差异 可变性 研究2受试者将在一年后招募重复 实验室、门诊和运动程序与研究相同 1. 研究3将检验以下假设： 相对较高的生活压力或挑战，这种差异将 与非反应堆相比，实验室HR反应堆最大。 36个 医学生将完成一个实验室会议，两个门诊 记录天数和一次分级运动测试。 1个门诊记录日 将是一个相对较低的挑战（去上课）的一天;另一个将 是一个相对高挑战的一天（病人护理实习）。 实验室、门诊和运动试验程序与 研究L。