DEVELOPMENT NEUROENDOCRINE CONTROL OF BEHAVIOR

行为的神经内分泌控制的发展

• 批准号: 3449705
• 负责人: CHRISTINA L WILLIAMS
• 金额: $ 4.93万
• 依托单位: BARNARD COLLEGE
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-03-01 至 1988-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3449705
• 关键词: animal developmental psychology; behavior test; estrogens; experimental brain lesion; female; gender difference; hormone regulation /control mechanism; hypothalamus; infant animal; neuroendocrine system; precocious puberty; progesterone; sex behavior

The major goals of the proposed research are to investigate the physiological mechanisms underlying the display of a hormone-facilitated behavior in the neonate and to trace their development. These studies are proposed in light of my recent finding that under certain conditions infant rats show components of receptive and proceptive behavior to tactile stimulation of the flanks. Moreover, these responsess are facilitated by exogeneous steroids during the first postanatal week when endogenous steroids are presumably sensitizing the neural circuitry underlying sexually dimorphic behavior. The proposed experiments first, determine the site and mechanism of estrogen activation of precocious reproductive function and second, describe the changes that occur as the responses become more steroid dependent, as sex differences in steroid sensitivity emerge, and as the eliciting stimuli become more specified. This analysis should provide new insights into the functional development of the neural systems mediating female sexual behavior and the process of sexual differentiation of brain and behavior.

拟议研究的主要目标是调查 激素促进的生理机制 新生儿的行为并追踪其发育。 这些研究是 根据我最近的发现提出，在某些条件下婴儿 老鼠表现出对触觉的接受和感知行为的组成部分 刺激侧翼。 此外，这些反应是通过 产后第一周内源性类固醇 类固醇可能使潜在的神经回路变得敏感 性二态行为。 首先提出实验，确定 性早熟雌激素激活部位及机制 其次，描述响应时发生的变化 由于类固醇敏感性的性别差异，变得更加依赖类固醇 出现，并且随着引发刺激变得更加具体。 本次分析 应该为神经功能发展提供新的见解 调节女性性行为和性过程的系统 大脑和行为的分化。

项目成果

Organizational effects of early gonadal secretions on sexual differentiation in spatial memory.

• DOI: 10.1037//0735-7044.104.1.84
• 发表时间: 1990-02
• 期刊: Behavioral neuroscience
• 影响因子: 1.9
• 作者: Christina L. Williams;Allison M. Barnett;W. Meck

Organizational changes in cholinergic activity and enhanced visuospatial memory as a function of choline administered prenatally or postnatally or both.

• DOI: 10.1037//0735-7044.103.6.1234
• 发表时间: 1989-12
• 期刊: Behavioral neuroscience
• 影响因子: 1.9
• 作者: Warren H. Meck;Rebecca A. Smith;Christina L. Williams

A reevaluation of the concept of separable periods of organizational and activational actions of estrogens in development of brain and behavior.

重新评估雌激素在大脑和行为发育中的组织和激活作用的可分离时期的概念。

• DOI: 10.1111/j.1749-6632.1986.tb28019.x
• 发表时间: 1986
• 期刊: Annals of the New York Academy of Sciences
• 影响因子: 5.2
• 作者: Williams,CL

Huddling and independent feeding of neonatal rats can be facilitated by a conditioned change in behavioral state.

行为状态的条件性改变可以促进新生大鼠的蜷缩和独立喂养。

• DOI: 10.1002/dev.420190613
• 发表时间: 1986
• 期刊: Developmental psychobiology
• 影响因子: 2.2
• 作者: Sullivan,RM;Brake,SC;Hofer,MA;Williams,CL
• 通讯作者: Williams,CL

Brain transections differentially alter lordosis and ear wiggling of 6-day-old rats.

脑横断会不同程度地改变 6 日龄大鼠的脊柱前凸和耳朵摆动。

• DOI: 10.1037//0735-7044.101.6.819
• 发表时间: 1987
• 期刊: Behavioral neuroscience
• 影响因子: 1.9
• 作者: Williams,CL;Lorang,D
• 通讯作者: Lorang,D