DEVELOPMENT NEUROENDOCRINE CONTROL OF BEHAVIOR

行为的神经内分泌控制的发展

• 批准号: 3449703
• 负责人: CHRISTINA L WILLIAMS
• 金额: $ 5.6万
• 依托单位: BARNARD COLLEGE
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-03-01 至 1988-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3449703
• 关键词: animal developmental psychology; behavior test; estrogens; experimental brain lesion; female; gender difference; hormone regulation /control mechanism; infant animal; neuroendocrine system; precocious puberty; progesterone; sex behavior

The major goals of the proposed research are to investigate the physiological mechanisms underlying the display of a hormone-facilitated behavior in the neonate and to trace their development. These studies are proposed in light of my recent finding that under certain conditions infant rats show components of receptive and proceptive behavior to tactile stimulation of the flanks. Moreover, these responsess are facilitated by exogeneous steroids during the first postanatal week when endogenous steroids are presumably sensitizing the neural circuitry underlying sexually dimorphic behavior. The proposed experiments first, determine the site and mechanism of estrogen activation of precocious reproductive function and second, describe the changes that occur as the responses become more steroid dependent, as sex differences in steroid sensitivity emerge, and as the eliciting stimuli become more specified. This analysis should provide new insights into the functional development of the neural systems mediating female sexual behavior and the process of sexual differentiation of brain and behavior.

拟议研究的主要目标是调查 生理机制潜在的显示， 行为在新生儿和跟踪他们的发展。 这些研究 根据我最近的发现，在某些情况下，婴儿 大鼠对触觉表现出接受和感受行为的成分 侧腹的刺激。 此外，这些响应由 外源性类固醇在产后第一周， 类固醇可能会使潜在的神经回路变得敏感 两性异形行为 建议实验首先，确定 生殖性早熟雌激素激活部位及机制 第二，描述响应时发生的变化， 变得更加依赖类固醇，因为类固醇敏感性的性别差异 出现，并作为引发的刺激变得更加具体。 该分析 应该为神经系统的功能发育提供新的见解。 调节女性性行为和性过程的系统 大脑和行为的分化。