INTEGRATIVE CARDIORESPIRATORY CONTROL DURING EXERCISE

中枢指令和源于工作骨骼肌的反射是 导致心肺疾病的两种可能的控制机制 对运动的反应。即使这两个假设已经被研究过了 另外，人们对这两个控件之间的相互作用知之甚少 机械装置。因此，拟议的项目将试图将中环 猫的神经部位，既参与中枢指挥，又参与 外围反馈。一系列实验将在 麻醉的猫。第一，心肺对刺激的反应 在Forel的丘脑底区，一种激活中枢的动作 命令，将在病变放置在 据信与延髓部位(外侧网状核)有关 对肌肉收缩的反射性心血管反应。下一首, 肌肉收缩引起的心血管和呼吸系统反应 前根刺激将在消融前后进行测量。 FIELS of Forel.最后，前额神经刺激场和前根 刺激将分别在损伤前后进行。 小脑区(顶核)参与心肺活动 对运动的反应。在第二系列实验中，猫将被 用于慢性心血管测量的仪器，然后培训为 进行等长运动。这些有意识的猫科动物将在 在造成与麻醉猫相同的损伤后。 在最后一系列实验中，微电极记录将在 麻醉猫以确定Forel、顶核或 外侧网状核有适当的神经联系 中枢指挥和肌肉锻炼反馈的整合。它是 希望这些实验将确定中枢神经位置 将下行中央命令与外围反馈相结合，以提供 对锻炼的适当反应。这方面的知识可能对 临床医生有神经缺陷导致异常的患者 对运动的反应。

Central command and a reflex originating in working skeletal muscles are two possible control mechanisms responsible for the cardiorespiratory responses to exercise. Even though these two hypotheses have been studied separately, little is known about interactions between these two control mechanisms. Therefore the proposed project will attempt to locate central neural sites in cats that are involved in both central command and peripheral feedback. One series of experiments will be performed in anesthetized cats. First, the cardiorespiratory responses to stimulation in the subthalamic fields of Forel, a maneuver thought to activate central command, will be determined before and after lesions are placed in a medullary site (the lateral reticular nucleus) believed to be associated with the reflex cardiovascular responses to muscular contraction. Next, cardiovascular and ventilatory responses to muscular contraction induced by ventral root stimulation will be measured before and after ablation of the fields of Forel. Finally, fields of Forel stimulation and ventral root stimulation will be performed separately before and after lesioning a cerebellar area (the fastigial nucleus) involved in the cardiorespiratory responses to exercise. In a second series of experiments, cats will be instrumented for chronic cardiovascular measurements and then trained to perform isometric exercise. These conscious cats will be studied before and after making lesions identical to those made in the anesthetized cats. In a final series of experiments, microelectrode recordings will be made in anesthetized cats to establish if the fields of Forel, fastigial nucleus or the lateral reticular nucleus have appropriate neural connections for integration of central command and feedback from exercising muscles. It is hoped that these experiments will identify central neural sites that integrate descending central command with peripheral feedback to provide the appropriate responses to exercise. This knowledge may be useful to clinicians having patients with neurological deficits causing abnormal responses to exercise.