CONTROL OF THE RESPIRATORY SYSTEM BY THE HYPOTHALAMUS
CONTROL OF THE RESPIRATORY SYSTEM BY THE HYPOTHALAMUS
批准号:
3355067
负责人:
TONY G WALDROP
金额:
$7.19万
依托单位国家:
美国
项目类别:
财政年份:
1988
资助国家:
美国
项目状态:
已结题
起止时间:
1988-04-01 至 1992-03-31
关键词:
antiadrenergic agents baroreceptors cats chemical stimulation chemoreceptors electrostimulus experimental brain lesion hypothalamus microinjections neural information processing neurochemistry neuropharmacology neurotransmitters respiration regulatory center respiratory function respiratory reflex single cell analysis stretch reflex
中文摘要
这项建议中的研究目的是调查
下丘脑参与呼吸控制
系统。多项研究表明,
下丘脑参与调节某些心血管疾病
条件反射。例如,心血管反应
压力感受器和外周化学感受器的刺激
已知会被下丘脑中的位置改变。即使
这些受体的激活也会影响呼吸,几乎没有
研究检测了下丘脑在调节
呼吸反应。因此,研究的具体目的是
在这项提案中描述的是调查
下丘脑部位在调节呼吸反射和
测定下丘脑利用的神经递质
调节呼吸的部位。呼吸反射是
被研究的是那些通过刺激肺伸展而诱发的
受体(Hering-Breuer反射);2)外周化学受体;3)
中枢化学感受器和4)动脉压力感受器。三套
的实验将在麻醉的猫身上进行。首先,
不同脑区神经元“兴奋性状态”的变化
下丘脑对呼吸反射的部位将是
下定决心。兴奋性状态将由化学物质或
电刺激,并将通过电解性损伤降低
或通过对下丘脑部位进行局部降温。在第二组
对呼吸反射的影响的实验研究
向脑内微量注射神经递质安慰剂
将对下丘脑进行评估。最后,将确定是否
上面列出的呼吸刺激会改变放电频率
下丘脑神经元。从这些信息中获得的信息
实验应该增加对神经的整体理解。
控制呼吸。这些发现可能会提供对
神经异常导致了一些中枢神经系统
呼吸系统疾病。
英文摘要
The purpose of the research in this proposal is to investigate
hypothalamic involvement in the control of the respiratory
system. Several studies have demonstrated that areas in the
hypothalamus are involved in modulating some cardiovascular
reflexes. For example, the cardiovascular responses to
stimulation of baroreceptors and peripheral chemoreceptors are
known to be modified by sites in the hypothalamus. Even though
activation of these receptors also affects ventilation, almost no
research has examined a role of the hypothalamus in regulating
respiratory responses. Therefore, the specific aims of the studies
described in this proposal are to investigate a potential role of
hypothalamic sites in regulating respiratory reflexes and to
determine the neurotransmitters utilized by the hypothalamic
sites which modulate breathing. The respiratory reflexes to be
studied are those evoked by stimulation of 1) pulmonary stretch
receptors (Hering-Breuer reflex); 2) peripheral chemoreceptors; 3)
central chemoreceptors and 4) arterial baroreceptors. Three sets
of experiments will be performed in anesthetized cats. First, the
effects of changing the "excitability state" of neurons in selected
hypothalamic sites upon the respiratory reflexes will be
determined. The excitability state will be raised by chemical or
electrical stimulation and will be lowered by electrolytic lesions
or by focal cooling of hypothalamic sites. In a second set of
experiments the effects upon the respiratory reflexes of
microinjecting neurotransmitter antogonists into the
hypothalamus will be evaluated. Finally, it will be determined if
the respiratory stimuli listed above alter the discharge frequency
of hypothalamic neurons. The information gained from these
experiments should add to the overall understanding of the neural
control of respiration. These findings may offer insights into the
neurological abnormalities responsible for some central
respiratory disorders.
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会议论文
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CONTROL OF THE RESPIRATORY SYSTEM BY THE HYPOTHALAMUS
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资助金额:$13.99万
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CONTROL OF THE RESPIRATORY SYSTEM BY THE HYPOTHALAMUS
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批准号:3355066
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资助金额:$8.02万
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负责人:TONY G WALDROP
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依托单位:
INTEGRATIVE CARDIORESPIRATORY CONTROL DURING EXERCISE
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项目类别:
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依托单位:
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CENTRAL NEURAL MECHANISMS IN RESPONSE TO EXERCISE
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批准号:5213062
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项目类别:
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资助金额:$0.0万
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财政年份:--
-
负责人:TONY G WALDROP
-
依托单位:--
CENTRAL NEURAL MECHANISMS IN RESPONSE TO EXERCISE
-
批准号:3735879
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:TONY G WALDROP
-
依托单位:
海外基金