Chronic oral graft-versus-host disease: clinical risk factors, biochemical markers of disease activity and novel therapeutics

慢性口腔移植物抗宿主病：临床危险因素、疾病活动的生化标志物和新疗法

• 批准号: nhmrc : 1017351
• 负责人: Dr Katrusha Hull
• 金额: $ 8.95万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/chronic-oral-graft-novel-therapeutics/109853
• 关键词: Chronic; oral; graft; versus; host

Chronic graft-versus-host disease (GVHD) is a serious complication of bone marrow transplantation. The oral cavity is often affected. Aims: 1.Identify and validate risk factors for oral GVHD 2.Assess if specific salivary components reflect disease activity 3.Trial novel therapeutic for GVHD-associated dry mouth Saliva testing may offer a non-invasive method to monitor oral GVHD. Also, new and effective topical agents are greatly needed and will improve therapeutic options in oral GVHD

慢性移植物抗宿主病（GVHD）是骨髓移植的严重并发症。口腔经常受到影响。目标：1.识别和验证口腔GVHD的危险因素2.评估特定唾液成分是否反映疾病活动3.试验GVHD相关口干的新治疗唾液检测可能提供一种非侵入性方法来监测口腔GVHD。此外，新的和有效的局部药物是非常需要的，并将改善口服GVHD的治疗选择