Circadian mechanisms for sex differences in shift work tolerance

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It is well-established that women respond more poorly than men to shift work schedules, having more health complaints, more drowsiness and more accidents at work than men. The physiological cause of this sex difference is not known. Our research suggests that differences in the circadian rhythms of women and men may promote shift work intolerance in women. This study is designed to examine sex differences in the effect of office-level light on the biological clock during a simulated night shift.