Hyper-sensitivity of the circadian system to light in Delayed Sleep Phase Disorder

睡眠相位延迟障碍的昼夜节律系统对光高度敏感

• 批准号: nhmrc : 1087665
• 负责人: A/Pr Clare Anderson
• 金额: $ 25.26万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/hyper-sensitivity-circadian-phase-disorder/519178
• 关键词: Hyper; sensitivity; circadian; system; light

Delayed Sleep Phase Disorder (DSPD) is a circadian rhythm sleep disorder characterized by a difficulty in initiating sleep at night and difficulty in waking at times required for work or school. It is associated with excessive daytime sleepiness, reduced academic and work performance, increased anxiety and depression and reduced quality of life. This study examines increased sensitivity of the brain's 24-hour biological clock to light as a cause of the abnormal timing of sleep in DSPD.

延迟睡眠阶段障碍（DSPD）是一种昼夜节律睡眠障碍，其特征是夜间难以入睡，在工作或上学所需的时间难以醒来。它与白天过度嗜睡、学业和工作表现下降、焦虑和抑郁增加以及生活质量下降有关。这项研究探讨了大脑24小时生物钟对光线的敏感性增加是DSPD患者睡眠时间异常的原因之一。