OCEAN: One-stop-shop microstructure-sensitive perfusion/diffusion MRI: Application to vascular cognitive impairment

OCEAN：一站式微结构敏感灌注/扩散 MRI：在血管性认知障碍中的应用

• 批准号: EP/M006328/2
• 负责人: Alejandro Frangi
• 金额: $ 7.45万
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FM006328%2F2
• 关键词: OCEAN; stop; shop; microstructure; sensitive

The term "dementia" is used to describe a syndrome that results, initially, in cognitive function impairment and in many cases, a descending staircase of psychological dysfunction, leading eventually to death. It is a major socio-economic challenge with care costs approaching 1% of global GDP. Several conditions that lead to serious loss of cognitive ability are grouped under this syndrome, including Alzheimer's disease (AD), Vascular Dementia (VaD), Frontotemporal Dementia, etc. A high publicity announcement was made in 2012, by the Prime Minister, emphasising the high priority that should be given to dementia-related research and that funding will more than double in the immediate future, to partially remedy the fact that the overwhelming impact of the syndrome has been over-looked (Guardian, 26/3/12). On Dec 2013, the G8 Summit hosted in London brought together G8 ministers, researchers, pharmaceutical companies, and charities to develop co-ordinated global action on dementia. Dementia has marked adverse effects on the quality of life of tens of millions of people (both patients and carers) and exerts tremendous pressure on healthcare systems, especially when clear trends towards an ageing population, changing environmental influences and contemporary lifestyle choices are considered. Ca. 35M people suffer from dementia worldwide, a figure to quadruple by 2050. Europe and North America share a disproportionally high burden: the effects of ageing are particularly stark for these regions, exacerbating the healthcare provision implications. The Clinical Relevance: Vascular Cognitive Impairment (VCI). VCI defines alterations in cognition attributable to cerebrovascular causes, ranging from subtle or fixed deficits to full-blown dementia. VCI is a wide and accepted term referring to the "syndrome with evidence of clinical stroke or subclinical vascular brain injury and cognitive impairment affecting at least one cognitive domain", with resulting VaD being its most severe form. VaD is responsible for at least 20% of dementias, second only to AD, with a prevalence doubling every 5. 3 years. Several trials examined cholinesterase inhibitors for the treatment of vascular dementia, but the benefits are very modest, except in the individuals with a combination of AD and VaD. Vascular changes result in white matter (WM) damage (leukoaraiosis), which profoundly affect the fidelity of the information transfer underlying brain function and cognitive health8. Cerebral Magnetic Resonance Imaging (MRI) of Diffusion and Perfusion. MRI is a medical imaging technique affording non-invasive investigation of anatomy and tissue function, which is particularly suited to studying cognitive disorders due to its sensitivity and reliability. Our main interest is to characterise vascular and non-vascular tissues using quantitative diffusion and perfusion MR. Our overall aim is to characterise and quantify early differential alterations in brain blood transport and subsequent microstructural tissue damage using one-stop-shop perfusion/diffusion MR GSI incorporating novel MR signal models and optimal MR sequence design based on new human brain histomorphometric data in health and disease.

“痴呆”一词用于描述一种综合征，该综合征最初会导致认知功能障碍，在许多情况下会导致心理功能障碍，最终导致死亡。这是一项重大的社会经济挑战，护理成本接近全球 GDP 的 1%。导致认知能力严重丧失的几种疾病都属于这种综合症，包括阿尔茨海默病（AD）、血管性痴呆（VaD）、额颞叶痴呆等。总理在 2012 年发表了一项高调的宣传声明，强调应高度重视痴呆症相关研究，并在不久的将来将资金增加一倍以上，以部分弥补这一巨大影响的事实。 该综合征的发病机制一直被忽视（《卫报》，2012 年 3 月 26 日）。 2013 年 12 月，八国集团峰会在伦敦举行，八国集团部长、研究人员、制药公司和慈善机构齐聚一堂，共同制定应对痴呆症的全球协调行动。痴呆症对数以千万计的人（包括患者和护理人员）的生活质量产生了显着的不利影响，并对医疗保健系统造成了巨大的压力，特别是考虑到人口老龄化、不断变化的环境影响和当代生活方式选择的明显趋势。约。全球有 3500 万人患有痴呆症，到 2050 年这一数字将增加四倍。欧洲和北美承受着不成比例的沉重负担：老龄化对这些地区的影响尤其明显，加剧了医疗保健供应的影响。临床相关性：血管认知障碍（VCI）。 VCI 定义了由脑血管原因引起的认知改变，范围从微妙或固定的缺陷到全面的痴呆。 VCI 是一个广泛接受的术语，指的是“有临床中风或亚临床血管性脑损伤和影响至少一个认知领域的认知障碍证据的综合征”，由此产生的 VaD 是其最严重的形式。 VaD 导致至少 20% 的痴呆症，仅次于 AD，患病率每 5. 3 年翻一番。几项试验检验了胆碱酯酶抑制剂治疗血管性痴呆的效果，但除了同时患有 AD 和 VaD 的个体外，其益处非常有限。血管变化会导致白质 (WM) 损伤（白质疏松），从而深刻影响大脑功能和认知健康的信息传输保真度8。弥散和灌注的脑磁共振成像 (MRI)。 MRI 是一种医学成像技术，可对解剖结构和组织功能进行非侵入性研究，由于其敏感性和可靠性，特别适合研究认知障碍。我们的主要兴趣是使用定量扩散和灌注 MR 来表征血管和非血管组织。我们的总体目标是利用一站式灌注/扩散 MR GSI，结合新颖的 MR 信号模型和基于健康和疾病中新的人脑组织形态计量数据的最佳 MR 序列设计，来表征和量化脑血液运输的早期差异改变以及随后的微结构组织损伤。

项目成果

MULTI-X, a State-of-the-Art Cloud-Based Ecosystem for Biomedical Research

MULTI-X，最先进的基于云的生物医学研究生态系统

• DOI: 10.1109/bibm.2018.8621317
• 发表时间: 2018
• 作者: De Vila M

Bildverarbeitung für die Medizin 2018 - Algorithmen - Systeme - Anwendungen. Proceedings des Workshops vom 11. bis 13. März 2018 in Erlangen

Bildverarbeitung für die Medizin 2018 - 算法 - 系统 - Anwendungen。

• DOI: 10.1007/978-3-662-56537-7_4
• 发表时间: 2018
• 作者: Frangi A

Subject-specific multi-poroelastic model for exploring the risk factors associated with the early stages of Alzheimer's disease.

• DOI: 10.1098/rsfs.2017.0019
• 发表时间: 2018-02-06
• 期刊: Interface focus
• 影响因子: 4.4
• 作者: Guo L;Vardakis JC;Lassila T;Mitolo M;Ravikumar N;Chou D;Lange M;Sarrami-Foroushani A;Tully BJ;Taylor ZA;Varma S;Venneri A;Frangi AF;Ventikos Y
• 通讯作者: Ventikos Y

Histological data of axons, astrocytes, and myelin in deep subcortical white matter populations.

深层皮层下白质群中轴突、星形胶质细胞和髓磷脂的组织学数据。

• DOI: 10.1016/j.dib.2019.103762
• 发表时间: 2019
• 期刊: Data in brief
• 影响因子: 1.2
• 作者: Coelho S

Characterization of active and infiltrative tumorous subregions from normal tissue in brain gliomas using multiparametric MRI.

• DOI: 10.1002/jmri.25963
• 发表时间: 2018-10
• 期刊: Journal of magnetic resonance imaging : JMRI
• 作者: Fathi Kazerooni A;Nabil M;Zeinali Zadeh M;Firouznia K;Azmoudeh-Ardalan F;Frangi AF;Davatzikos C;Saligheh Rad H
• 通讯作者: Saligheh Rad H