Clinical Translation of a One-Stop-Shop Imaging Method for Abdominal CT

腹部 CT 一站式成像方法的临床转化

• 批准号: 10686103
• 负责人: Guang-Hong Chen
• 金额: $ 60.18万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10686103
• 关键词: Abdomen; Academic Medical Centers; Address; Adrenal Glands; Anatomy; Attenuated; Clinical; Community Hospitals; Compton radiation; Computed Tomography Scanners; Data; Data Set; Developing Countries; Development; Diagnosis; Diagnostic; Dose; Elements; Environment; Evaluation; Future; Health Care Costs; Hospitals; Image; Imaging Techniques; Incidental Findings; Iodine; Lipids; Magnetic Resonance Imaging; Maps; Measurement; Measures; Medical; Methods; Modern Medicine; Modernization; Modification; Nodule; Pathway interactions; Patients; Penetration; Performance; Phase; Photons; Process; Radiation Dose Unit; Radiology Specialty; Research; Resolution; Roentgen Rays; Scanning; Series; Signal Transduction; Source; Speed; System; Techniques; Technology; Translating; Tube; X-Ray Computed Tomography; X-Ray Medical Imaging; abdominal CT; absorption; adenoma; attenuation; clinical application; clinical diagnostics; clinical implementation; clinical practice; clinical translation; community clinic; contrast enhanced; contrast enhanced computed tomography; detector; diagnostic accuracy; diagnostic tool; disease diagnosis; experience; image reconstruction; imaging facilities; imaging modality; imaging system; improved; innovation; novel; quantitative imaging; radiation risk; spectral energy; success; technology platform; temporal measurement; tool; uptake; virtual

ABSTRACT CT imaging is one of the primary diagnostic tools utilized in modern radiology departments, and its importance to modern medicine cannot be overstated. In recent years, spectral CT technologies have been developed to address one of the long-standing technical limitations associated with conventional single-kV CT imaging: anatomical structures with different material compositions may have the same CT number for a given acquisition. Current spectral CT imaging systems have been implemented using advanced x-ray source and/or detector technologies that enable image objects to be rapidly scanned using two distinct x-ray spectra. However, these hardware-based spectral CT systems are not without their own intrinsic limitations. Such limitations include a reduced field-of-view, slower scan speeds, misregistration between the high kV and low kV measurements in dual source systems, lack of tube current modulation for many fast kV-switching systems, and having other clinical workflow/efficiency challenges. In this application, we propose to implement and translate a novel single- kV spectral CT imaging method for abdominal CT applications that overcomes the limitations associated with current spectral CT imaging methods. With this new method, all conventional contrast-enhanced single-kV abdominal CT exams can be used to generate a deluxe series of CT images with the desired spectral CT functionalities including virtual non-contrast CT images, virtual mono-energetic CT images, and quantitative material basis images (i.e., one-stop-shop). This new method enables an integrated clinical workflow to improve clinical diagnostic accuracy while reducing both radiation dose and contrast dose to patients, all while reducing overall healthcare costs. Three specific aims will be carried out to accomplish the overarching objective of this project: 1) Implement and optimize techniques to achieve one-stop-shop single-kV spectral CT imaging for abdominal applications; 2) Validate the proposed one-stop-shop single-kV spectral CT imaging method using the hardware based spectral CT imaging methods; and 3) translate the one-stop-shop single-kV spectral CT imaging method to the clinical environment for clinical performance evaluations. Upon the completion of this project, a unique one-stop-shop CT imaging paradigm will have been implemented and translated to clinical abdominal CT exams to enable one-stop-shop abdominal CT diagnoses with just a single-kV contrast-enhanced CT acquisition. This new technique can be made available to all types of imaging facilities including community hospitals or clinics in developing nations, which is in stark contrast to hardware dual-energy CT and photon counting CT imaging which has been traditionally reserved to high profile academic medical centers that can afford the latest technological platforms.

抽象的 CT成像是现代放射学部门使用的主要诊断工具之一，其重要性 对现代医学不能被夸大。近年来，Spectral CT技术已开发为 地址与常规单KV CT成像相关的长期技术限制之一： 具有不同材料组成的解剖结构对于给定采集可能具有相同的CT数。 当前的光谱CT成像系统已使用高级X射线源和/或检测器实现 可以使用两个不同的X射线光谱快速扫描图像对象的技术。但是，这些 基于硬件的光谱CT系统并非没有自己的固有限制。这样的限制包括 视野降低，扫描速度较慢，高kV和低kV测量之间的误会 双源系统，缺乏许多快速KV开关系统的管当电流调制，以及其他 临床工作流程/效率挑战。在此应用中，我们建议实施和翻译一种新颖的单一单一 腹部CT应用的KV光谱CT成像方法克服了与 当前的光谱CT成像方法。使用这种新方法，所有常规的对比度增强的单kV 腹部CT考试可用于生成具有所需光谱CT的豪华系列CT图像 功能包括虚拟非对比度CT图像，虚拟单能CT图像和定量 物质基础图像（即一站式车站）。这种新方法可实现集成的临床工作流程以改进 临床诊断准确性，同时减少对患者的辐射剂量和对比剂量，同时还原 总体医疗保健费用。将实现三个具体目标以实现这一目标的总体目标 项目：1）实施并优化技术以实现一站式单kV光谱CT成像 腹部应用； 2）使用使用的一站式单kV频谱CT成像验证提出的一站式单家 基于硬件的光谱CT成像方法； 3）翻译一站式单kV光谱CT 对临床环境进行临床性能评估的成像方法。完成此完成 项目，将实施独特的一站式CT成像范式，并将其转换为临床 腹部CT考试可以使一站式腹部CT诊断仅具有单kV对比度增强 CT收购。该新技术可以提供给包括社区在内的所有类型的成像设施 发展中国家的医院或诊所，与硬件双能CT和Photon形成鲜明对比 计算传统上保留给知名的学术医疗中心的CT成像 提供最新的技术平台。