Circadian rhythm disruption and metabolic function

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Shiftwork is an under-researched risk factor for obesity and diabetes. Because shiftwork disrupts hormonal and sleep rhythmicity, eating patterns and light exposure, abnormal rhythmicity may be a causal factor in metabolic disease. Direct evidence for the link is lacking and the underlying mechanisms responsible are unknown. This project aims to understand how shiftwork may lead to diabetes and obesity, knowledge essential for the design and testing of potential interventions.