Ultrafast contrast enhanced ultrasound for imaging and quantifying flow and tissue perfusion

超快对比增强超声用于成像和量化血流和组织灌注

• 批准号: EP/M011933/1
• 负责人: Mengxing Tang
• 金额: $ 48.78万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FM011933%2F1
• 关键词: Ultrafast; contrast; enhanced; ultrasound; imaging

Imaging and quantifying blood flow and perfusion are critical to the diagnosis and management of a range of major diseases including coronary heart disease, valvular heart disease, carotid, cerebral and peripheral vascular diseases, cancer, and chronic inflammation, all of which manifest themselves with abnormalities in flow and perfusion. Existing imaging and quantification techniques have numerous limitations. Ultrasound imaging is one of the most widely used clinical imaging methods, offering safety, real-time imaging, low cost and excellent accessibility. Recent advances in ultrafast ultrasound techniques can increase ultrasound imaging speed by up to two orders of magnitude and have resulted in exciting developments in non-contrast enhanced ultrasound applications, including soft tissue elastography, brain functional imaging and cardiac imaging. If combined with advances in contrast enhanced ultrasound (CEUS) using microbubble contrast agents, the ultrafast techniques have the potential to improve the conspicuity of the contrast agent by up to 10 times and greatly extend the field of view or the dynamic range of blood flows that can be tracked through ultrasound; these hitherto unrealised improvements could dramatically impact the ability to image and quantify flow and perfusion. In this project we propose to develop and evaluate novel ultrafast CEUS methodologies and systems for this purpose, building on our extensive research experiences on microbubble contrast agent imaging. They have the potential to become the next generation ultrasound tools for pre-clinical and clinical imaging of blood flow and tissue perfusion, giving unprecedented performance in terms of accuracy, SNR, sensitivity, specificity and resolution.

成像和量化血流和灌注对于一系列重大疾病的诊断和管理至关重要，包括冠心病、心脏瓣膜病、颈动脉、脑和外周血管疾病、癌症和慢性炎症，所有这些疾病都表现为血流和灌注异常。现有的成像和量化技术具有许多限制。超声成像是最广泛使用的临床成像方法之一，具有安全性、实时成像、低成本和良好的可及性。超快超声技术的最新进展可以将超声成像速度提高两个数量级，并在非对比增强超声应用中取得了令人兴奋的发展，包括软组织弹性成像、脑功能成像和心脏成像。如果与使用微泡造影剂的造影增强超声（CEUS）的进步相结合，超快技术有可能将造影剂的显着性提高多达10倍，并大大扩展可以通过超声跟踪的血流的视野或动态范围;这些迄今未实现的改进可能会极大地影响成像和量化血流和灌注的能力。在这个项目中，我们建议开发和评估新的超快CEUS方法和系统，为此目的，建立在我们广泛的研究经验，微泡造影剂成像。它们有可能成为下一代超声工具，用于血流和组织灌注的临床前和临床成像，在准确性，SNR，灵敏度，特异性和分辨率方面提供前所未有的性能。

项目成果

Super-resolution Ultrasound Imaging.

• DOI: 10.1016/j.ultrasmedbio.2019.11.013
• 发表时间: 2020-04
• 期刊: Ultrasound in medicine & biology
• 影响因子: 2.9
• 作者: Christensen-Jeffries K;Couture O;Dayton PA;Eldar YC;Hynynen K;Kiessling F;O'Reilly M;Pinton GF;Schmitz G;Tang MX;Tanter M;van Sloun RJG
• 通讯作者: van Sloun RJG

Contrast Agent-Free Assessment of Blood Flow and Wall Shear Stress in the Rabbit Aorta using Ultrasound Image Velocimetry.

• DOI: 10.1016/j.ultrasmedbio.2021.10.010
• 发表时间: 2022-03
• 期刊: Ultrasound in medicine & biology
• 影响因子: 2.9
• 作者: Riemer K;Rowland EM;Broughton-Venner J;Leow CH;Tang M;Weinberg PD
• 通讯作者: Weinberg PD

Intimal and medial contributions to the hydraulic resistance of the arterial wall at different pressures: a combined computational and experimental study.

• DOI: 10.1098/rsif.2016.0234
• 发表时间: 2016-06
• 期刊: Journal of the Royal Society, Interface
• 作者: Chooi KY;Comerford A;Sherwin SJ;Weinberg PD
• 通讯作者: Weinberg PD