A Novel Ultrasound Modulated Optical Tomography System

一种新型超声调制光学断层扫描系统

• 批准号: EP/H02316X/1
• 负责人: Mengxing Tang
• 金额: $ 14.74万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FH02316X%2F1
• 关键词: Novel; Ultrasound; Modulated; Optical; Tomography

Optical imaging of biological tissue is able to provide structural and functional information, which potentially enables early detection of abnormalities such as tumours and detection of tissue oxygenation. However, one disadvantage of such technique is the difficulty to image objects at depth. By comparison, ultrasound imaging is able to provide good image resolution at depth and is an established clinical imaging modality. However, ultrasound imaging is based on the detection of the mechanical properties in tissues which is not as sensitive as optical techniques in e.g. detecting tumours.Ultrasound-modulated optical tomography (UOT) is a new technique to take advantage of the combined strengths of the two imaging modalities. In UOT, light is transmitted into the target tissue and at the same time an ultrasonic wave is focused into the tissue to modulate the light. The scattered light from the tissue can be measured and images of tissue optical properties can be reconstructed, with a spatial resolution primarily defined by ultrasound. Studies of UOT as a medical imaging tool only began in the 90s. Although promising images have been produced with laboratory phantoms and excised tissues, a significant challenge of the current UOT technique is the weak optical modulation signal to be measured. A direct way to tackle the problem of weak optical signal is to maximise the ultrasonic modulation of all light passing through the ultrasound focus. Past studies show that simply increasing the ultrasound amplitude may not be sufficient and also has some adverse effects. In this project, we propose to develop a novel UOT system with dual-frequency ultrasound excitation to maximise the modulated light signal. In this pilot study both a computer simulation system and an experimental system will be developed and results compared with the conventional UOT system. This new system has the potential to significantly improve UOT image quality.

生物组织的光学成像能够提供结构和功能信息，这有可能实现肿瘤等异常的早期检测和组织氧合作用的检测。然而，这种技术的一个缺点是难以对深度处的对象进行成像。相比之下，超声成像能够在深度提供良好的图像分辨率，并且是已建立的临床成像模式。然而，超声成像是基于对组织中的机械特性的检测，在检测肿瘤等方面不如光学技术灵敏。超声调制光学断层成像（UOT）是一种利用两种成像模式的综合优势的新技术。在UOT中，光被传输到目标组织中，同时超声波被聚焦到组织中以调制光。可以测量来自组织的散射光，并且可以重建组织光学特性的图像，其中空间分辨率主要由超声定义。UOT作为医学成像工具的研究始于90年代。虽然有前途的图像已经产生与实验室幻影和切除的组织，目前的UOT技术的一个重大挑战是微弱的光调制信号进行测量。解决弱光信号问题的直接方法是最大化通过超声焦点的所有光的超声调制。过去的研究表明，简单地增加超声振幅可能是不够的，也有一些不利影响。在这个项目中，我们建议开发一种新型的UOT系统，具有双频超声激励，以最大限度地提高调制光信号。在这项试点研究中，将开发计算机模拟系统和实验系统，并将结果与传统的UOT系统进行比较。这种新系统有可能显着提高UOT图像质量。

项目成果

Dual shear wave induced laser speckle contrast signal and the improvement in shear wave speed measurement.

• DOI: 10.1364/boe.6.001954
• 发表时间: 2015-06
• 期刊: Biomedical optics express
• 影响因子: 3.4
• 作者: Sinan Li;Yi Cheng;R. Eckersley;D. Elson;M. Tang

Parallel detection of amplitude-modulated, ultrasound-modulated optical signals.

• DOI: 10.1364/ol.35.002633
• 发表时间: 2010-08
• 期刊: Optics letters
• 影响因子: 3.6
• 作者: Rui Li;Lipei Song;D. Elson;M. Tang