QUANTITATIVE ANALYSIS OF MASTICATORY DYSFUNCTION

咀嚼功能障碍的定量分析

• 批准号: 3462462
• 负责人: GEOFFREY EUGENE GERSTNER
• 金额: $ 8.4万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-08-01 至 1997-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3462462
• 关键词: diagnosis design /evaluation; electromyography; human population study; human subject; joint disorder; longitudinal human study; mastication; muscle disorder diagnosis; muscle disorders; oral facial pain; pathologic process; questionnaires; sign /symptom; statistics /biometry; temporomandibular joint; videotape /videodisc

The long term objectives of this proposal are: 1) to create a comprehensive quantified description of mastication in non-diseased human subjects and subjects with specific temporomandibular disorders (TMD) 2, to identify the specific features of mastication that differentiate between non-diseased human subjects and TMD subjects, 3) to identify time-dependent changes in the mastication of the TMD and non-diseased subjects over a three year period, and 4) to determine whether the level of masticatory dysfunction in TMD subjects is correlated with TMD symptom sign and severity. To fulfill these objectives, the proposed experiments will use a recently developed tool in order to create a detailed quantified description of jaw movement and EMG activity parameters in the subjects. The selected parameters have provided significant insight into mastication in previous studies. The measures of these parameters will then be used in a discriminant analysis to determine the extent to which the mastication of TMD subjects is different from the mastication of the non-diseased subjects. At the same time, the specific parameters that differentiate between the subject groups will be identified. Next, the masticatory parameters will be quantified repeatedly over a three year period and then analyzed with a multivariate analysis of variance, repeated measure design in order to identify time-dependent changes in mastication. Finally, a multivariate distance measure (i.e. the standard distance) between each TMD subject and the non-diseased group mean will be calculated. This distance measure defines how far each TMD subject is from the non- diseased group mean; therefore, it can be used as an "index of dysfunction". This index will be correlated with TMD symptom sign and severity in order to identify whether symptom severity and dysfunction severity are highly correlated. The proposed experiments are essential, since scientific work in the area of masticatory dysfunction has only just begun, and currently, much confusion exists regarding "normal" and "abnormal" mastication. The proposed studies will help significantly in reducing this confusion. They will provide valuable insight into the relationship between masticatory dysfunction and TMD disease progression. They will also provide significant information regarding masticatory adaptation processes. Finally, the study of associated EMG activity will provide invaluable information regarding electrophysiological changes associated with the disease. All of these results are critical in order to determine precisely the etiology, epidemiology, progression and treatment of TMD.

该提案的长期目标是： 1) 创建一个 无病咀嚼的全面量化描述 人类受试者和患有特定颞下颌疾病的受试者 （TMD）2、识别咀嚼的具体特征 区分未患病人类受试者和 TMD 受试者，3) 识别 TMD 咀嚼随时间的变化 三年内未患病的受试者，以及 4) 确定 TMD 受试者的咀嚼功能障碍水平是否为 与 TMD 症状体征和严重程度相关。 为了实现这些 目标，拟议的实验将使用最近开发的工具 为了创建下颌运动的详细量化描述 受试者的肌电图活动参数。 所选参数有 在以前的研究中提供了对咀嚼的重要见解。 这 这些参数的测量将用于判别式 分析以确定TMD的咀嚼程度 受试者的咀嚼与非患病受试者不同。 同时，区分的具体参数 将确定主题组。 接下来是咀嚼参数 将在三年内反复量化，然后进行分析 通过多变量方差分析、重复测量设计 为了识别咀嚼时间依赖性的变化。 最后，一个 每个之间的多元距离测量（即标准距离） 将计算TMD受试者和非患病组的平均值。 这个距离测量定义了每个TMD对象与非TMD对象的距离。 患病组平均值；因此，它可以作为“指数” 该指标将与TMD症状体征和相关性相关 严重程度，以确定症状的严重程度和功能障碍是否严重 严重程度高度相关。 所提出的实验是必不可少的， 因为咀嚼功能障碍领域的科学工作仅 刚刚开始，目前，关于“正常”和“正常”存在很多混乱 “异常”咀嚼。 拟议的研究将大大有助于 减少这种混乱。 他们将提供宝贵的见解 咀嚼功能障碍与TMD病的关系 进展。 他们还将提供有关以下方面的重要信息： 咀嚼适应过程。 最后，相关肌电图的研究 活动将提供有关以下方面的宝贵信息： 与疾病相关的电生理变化。 所有这些 结果对于准确确定病因至关重要， TMD 的流行病学、进展和治疗。