QUANTITATIVE ANALYSIS OF MASTICATORY DYSFUNCTION

这项提议的长期目标是：1)创建一个 非病变者咀嚼功能的综合量化描述 人类受试者和患有特定颞颌关节紊乱病的受试者 (TMD)2，确定咀嚼的具体特征 区分正常人和TMD受试者，3) 确定TMD咀嚼的随时间的变化，并 三年内未患病的受试者，以及4)确定 TMD受试者的咀嚼功能障碍水平是否 与TMD症状、体征及严重程度相关。为了实现这些目标 目标，拟议的实验将使用最近开发的工具 为了创建对颌骨运动的详细量化描述和 受试者的肌电活动参数。所选参数具有 在以前的研究中提供了对咀嚼的重要见解。这个 然后，这些参数的测量将被用于判别 分析确定TMD的咀嚼程度 受试者的咀嚼与非患病受试者的咀嚼不同。 同时，区分 将确定主题组。接下来，咀嚼参数 将在三年内重复量化，然后分析 通过多变量方差分析，重复测量设计在 以确定咀嚼中随时间变化的情况。最后，一个 两者之间的多元距离度量(即标准距离) 将计算TMD受试者和非患病组的平均值。 此距离度量定义每个TMD对象与非TMD对象之间的距离 疾病组均值；因此，它可以作为一种 这一指标与TMD症状体征和 严重程度，以确定症状严重程度和功能障碍 严重程度高度相关。拟议中的实验是必不可少的， 由于咀嚼功能障碍领域的科学工作只有 这才刚刚开始，目前，人们对“正常”和“正常” “不正常”的咀嚼。拟议的研究将对以下方面有重大帮助 减少这种困惑。他们将提供有价值的洞察 咀嚼功能障碍与TMD病的关系 进步。他们还将提供重要的信息，如 咀嚼适应过程。最后，对相关肌电进行了研究 活动将提供以下宝贵的信息： 与疾病相关的电生理变化。所有这些都是 为了准确地确定病因，结果至关重要， TMD的流行病学、进展和治疗。

The long term objectives of this proposal are: 1) to create a comprehensive quantified description of mastication in non-diseased human subjects and subjects with specific temporomandibular disorders (TMD) 2, to identify the specific features of mastication that differentiate between non-diseased human subjects and TMD subjects, 3) to identify time-dependent changes in the mastication of the TMD and non-diseased subjects over a three year period, and 4) to determine whether the level of masticatory dysfunction in TMD subjects is correlated with TMD symptom sign and severity. To fulfill these objectives, the proposed experiments will use a recently developed tool in order to create a detailed quantified description of jaw movement and EMG activity parameters in the subjects. The selected parameters have provided significant insight into mastication in previous studies. The measures of these parameters will then be used in a discriminant analysis to determine the extent to which the mastication of TMD subjects is different from the mastication of the non-diseased subjects. At the same time, the specific parameters that differentiate between the subject groups will be identified. Next, the masticatory parameters will be quantified repeatedly over a three year period and then analyzed with a multivariate analysis of variance, repeated measure design in order to identify time-dependent changes in mastication. Finally, a multivariate distance measure (i.e. the standard distance) between each TMD subject and the non-diseased group mean will be calculated. This distance measure defines how far each TMD subject is from the non- diseased group mean; therefore, it can be used as an "index of dysfunction". This index will be correlated with TMD symptom sign and severity in order to identify whether symptom severity and dysfunction severity are highly correlated. The proposed experiments are essential, since scientific work in the area of masticatory dysfunction has only just begun, and currently, much confusion exists regarding "normal" and "abnormal" mastication. The proposed studies will help significantly in reducing this confusion. They will provide valuable insight into the relationship between masticatory dysfunction and TMD disease progression. They will also provide significant information regarding masticatory adaptation processes. Finally, the study of associated EMG activity will provide invaluable information regarding electrophysiological changes associated with the disease. All of these results are critical in order to determine precisely the etiology, epidemiology, progression and treatment of TMD.