QUANTITATIVE ANALYSIS OF MASTICATORY DYSFUNCTION

这项建议的长远目标是：1）建立一个 非疾病咀嚼功能的全面量化描述 人类受试者和患有特定颞下颌关节紊乱病的受试者 (TMD)2、识别咀嚼的具体特征， 区分未患病的人类受试者和TMD受试者，3） 确定TMD咀嚼的时间依赖性变化， 在三年的时间内，非患病受试者，以及4）确定 TMD患者的咀嚼功能障碍水平是否 与TMD症状体征及严重程度相关。 满足这些 目标，拟议的实验将使用最近开发的工具， 为了创建颌运动的详细量化描述， 受试者的EMG活动参数。 所选参数包括 在以前的研究中对咀嚼提供了重要的见解。 的 这些参数的测量将用于判别式 分析确定TMD咀嚼的程度 受试者的咀嚼不同于非患病受试者的咀嚼。 与此同时，区分 将确定主题组。 接下来，咀嚼参数 将在三年内反复量化， 采用多变量方差分析，重复测量设计， 以确定咀嚼的时间依赖性变化。 最后 多变量距离度量（即标准距离） TMD受试者和非疾病组平均值 将被计算。 该距离测量定义了每个TMD受试者与非受试者的距离 疾病组平均值;因此，它可以用作"指数"。 功能障碍"。 该指标与TMD症状体征、 严重程度，以确定症状的严重程度和功能障碍 严重性是高度相关的。 拟议的实验是必不可少的， 因为咀嚼功能障碍领域的科学工作 刚刚开始，目前，关于"正常"和 "异常"咀嚼。 拟议的研究将大大有助于 减少这种混乱。 他们将提供宝贵的见解， 颞下颌关节紊乱病与咀嚼功能障碍的关系 进展 他们还将提供重要信息， 咀嚼适应过程 最后，对关联肌电的研究 活动将提供宝贵的信息， 与疾病相关的电生理变化。 所有这些 结果对于精确确定病因是至关重要的， TMD的流行病学、进展和治疗。

The long term objectives of this proposal are: 1) to create a comprehensive quantified description of mastication in non-diseased human subjects and subjects with specific temporomandibular disorders (TMD) 2, to identify the specific features of mastication that differentiate between non-diseased human subjects and TMD subjects, 3) to identify time-dependent changes in the mastication of the TMD and non-diseased subjects over a three year period, and 4) to determine whether the level of masticatory dysfunction in TMD subjects is correlated with TMD symptom sign and severity. To fulfill these objectives, the proposed experiments will use a recently developed tool in order to create a detailed quantified description of jaw movement and EMG activity parameters in the subjects. The selected parameters have provided significant insight into mastication in previous studies. The measures of these parameters will then be used in a discriminant analysis to determine the extent to which the mastication of TMD subjects is different from the mastication of the non-diseased subjects. At the same time, the specific parameters that differentiate between the subject groups will be identified. Next, the masticatory parameters will be quantified repeatedly over a three year period and then analyzed with a multivariate analysis of variance, repeated measure design in order to identify time-dependent changes in mastication. Finally, a multivariate distance measure (i.e. the standard distance) between each TMD subject and the non-diseased group mean will be calculated. This distance measure defines how far each TMD subject is from the non- diseased group mean; therefore, it can be used as an "index of dysfunction". This index will be correlated with TMD symptom sign and severity in order to identify whether symptom severity and dysfunction severity are highly correlated. The proposed experiments are essential, since scientific work in the area of masticatory dysfunction has only just begun, and currently, much confusion exists regarding "normal" and "abnormal" mastication. The proposed studies will help significantly in reducing this confusion. They will provide valuable insight into the relationship between masticatory dysfunction and TMD disease progression. They will also provide significant information regarding masticatory adaptation processes. Finally, the study of associated EMG activity will provide invaluable information regarding electrophysiological changes associated with the disease. All of these results are critical in order to determine precisely the etiology, epidemiology, progression and treatment of TMD.