TOXIC FACTORS AFFECTING BONE QUALITY DURING GROWTH

建议的研究重点是环境毒素对环境的影响。 骨骼生长过程中的材料特性。大分子的变化 有毒物质引起的骨组织的组成和组织 与骨骼的大体结构改变有关。这项研究将 对骨骼特性的一般理论做出贡献，这将有助于 防治骨病。 足够质量的骨骼对于预防或预防骨质疏松症至关重要 发病和/或减轻常见成人骨骼疾病的严重程度，如 骨质疏松症和骨关节炎。无处不在的环境毒素使 有必要了解骨密度、僵硬、胶原纤维 可以将横截面上的骨的结构和空间排列 受这些物质的影响。生长中的骨骼对 生命早期的环境侮辱和骨组织质量下降可能 导致成年人患骨病的风险增加。因此，它是 认识控制成矿和矿化的机制(S) 骨骼在生长过程中的弹性特性。 弹性性质，尺寸随含水率、成分、 密度、中子衍射、交联密度和截面 几何属性是用来刻画正常和病理特征 处于不同生长阶段的骨骼。骨病理是在以下条件下诱发的 通过饮食手段使用β-氨基丙腈很好地控制了条件- -甜豌豆苏铁的有毒衍生品--热带食物来源 含有致命的毒素和氟化物。来自物理测量的数据 组织将与形态计量学和 组织形态计量学分析在骨病理综合评价中的应用 由有毒物质引起的。

The proposed research focuses on the effect environmental toxins on the material properties of bone during growth. Changes in the macromolecular composition and organization of bone tissue due to toxic substances will be related to alteration in gross architecture of bone. The study will contribute to a general theory of bone properties which will aid in the prevention and treatment of bone disease. Bone of sufficient quality is essential to preventing or forestalling the onset and/or reducing the severity of common adult bone diseases like osteoporosis and osteoarthritis. The ubiquity of environmental toxins make it imperative to understand how bone density, stiffness, collagen fibril structure and the spatial arrangement of bone in cross-section can be affected by these substances. Growing bone is particularly sensitive to environmental insults and reduced bone tissue quality early in life may lead to increased risk of bone disease in adults. It is therefore important to understand the mechanism(s) which control mineralization and elastic properties of bone during growth. Elastic properties, dimensional change with water content, composition, density, neutron diffraction, cross-linking density, and cross-sectional geometric properties are measure to characterize normal and pathological bone at different stages of growth. Bone pathologies are induced under well-controlled conditions by dietary means using beta-aminopropionitrile - - a toxic derivative of the sweet pea, cycads -- a tropical food source containing lethal toxins, and fluoride. Data from physical measurements of the tissue will be combined with data from morphometric and histomorphometric analyses for a comprehensive evaluation of bone pathology induced by toxic substances.