Scimagix Web-Based Scientific Image Management System

Scimagix 基于网络的科学图像管理系统

• 批准号: 6876349
• 负责人: Douglas Burke Hanson
• 金额: $ 36.78万
• 依托单位: ADA FORSYTH INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-15 至 2006-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6876349
• 关键词: Internet; bioimaging /biomedical imaging; biomedical equipment purchase; computer program /software; computer system hardware; craniofacial; digital imaging; oral pharyngeal

DESCRIPTION (provided by applicant): This proposal requests funds for The Forsyth Institute to establish a shared, web-based scientific image management system (SIMS) using commercially available software from Scimagix, Inc. (http://www.scimagix.com). Funds are being requested for the: (1) Scimagix SIMS application software, (2) application server hardware required for SIMS, (3) the disk array for image storage, (4) Oracle 9i database software application which serves as the backend to SIMS, (5) server hardware required for operation of Oracle 9i, and (6) tape backup system for backup and recovery of images and data in the event of server hardware failure. Forsyth is recognized internationally as the world's foremost independent research institute focusing on oral and craniofacial biology. In order to maintain high standards of achievement in research, cutting edge instrumentation and appropriate software tools must be readily available to its investigators. Currently, Forsyth investigators generate more than 10GB of high resolution image data/week and there is no effective means of storing, searching and retrieving these images. Nearly all images are stored on removable media, primarily CDROM and Zip floppies. Some are scattered throughout the file systems on hard-drives or the Forsyth network. Digital imaging sources at Forsyth include, but are not limited to, EM and TEM, confocal laser scanning microscopy (CLSM), laser capture microdissection microscopy, atomic force microscopy, microradiography, digital still and video imaging through light microscopes, UV and fluorescent microscopy, digital radiography and intraoral digital photography. Most of the laboratories at Forsyth are equipped with at least 1 digital microscope, either stand-alone or attached to a computer workstation. Scimagix's SIMS will provide a user-friendly means to facilitate the storage, search and retrieval of images for use in research and publication at Forsyth and will immediately benefit 17 of the total projects at Forsyth. These projects can be grouped into a number of broad categories based on the kinds of imaging technologies utilized in the research: (1) the study of oral biofilm formation, the interaction of biofilm with epithelial cells, and the immune response to biofilm using images generated from the CLSM; (2) mapping gene expression using in situ hybridization and CLSM (3) global expression of genes in oral bacteria from high throughput screening of digital microarrays; (4) the study of specific gene and protein expressions using a fluorescent imaging system (STORM 840) and the optical sectioning capabilities of the CLSM; and (5) mechanisms of gene regulation in bone resorption by localizing gene expression, protein elaboration and molecular interactions in osteoclasts using CLSM and micro CT. The Forsyth Institute guarantees to provide for: (1) housing in the Office of Computing & Network Technology for the additional server hardware needed to support the SIMS application; (2) installation and end-user training costs; (3) onsite consulting during software implementation; (4) Oracle training for Forsyth's database administrator; (5) annual software maintenance for both the SIMS application and the Oracle 9i database software and (6) permanent in house support.

描述（由申请人提供）：本提案要求为福赛斯研究所提供资金，以使用Scimagix，Inc.的市售软件建立一个共享的、基于网络的科学图像管理系统（西姆斯）。(http：www.scimagix.com）的示例。目前正在为以下活动申请资金：（1）Scimagix西姆斯应用软件，（2）西姆斯所需的应用服务器硬件，（3）用于图像存储的磁盘阵列，（4）用作西姆斯后端的Oracle 9 i数据库软件应用程序，（5）Oracle 9 i操作所需的服务器硬件，以及（6）磁带备份系统，用于在服务器硬件发生故障时备份和恢复图像和数据。福赛斯是国际公认的世界上最重要的独立研究机构，专注于口腔和颅面生物学。为了保持高标准的研究成果，尖端仪器和适当的软件工具必须随时提供给研究人员。目前，福赛斯研究人员每周产生超过10 GB的高分辨率图像数据，并且没有有效的方法来存储、搜索和检索这些图像。几乎所有的图像都存储在可移动介质上，主要是CDROM和Zip软盘。有些分散在硬盘驱动器或福赛斯网络上的文件系统中。福赛斯的数字成像源包括但不限于EM和TEM、共聚焦激光扫描显微镜（CLSM）、激光捕获显微切割显微镜、原子力显微镜、显微放射照相术、通过光学显微镜的数字静止和视频成像、UV和荧光显微镜、数字放射照相术和口内数字摄影。福赛斯的大多数实验室都配备了至少一台数字显微镜，可以是独立的，也可以是连接到计算机工作站的。Scimagix的西姆斯将提供一个用户友好的方式，以促进存储，搜索和检索图像用于研究和出版在福赛斯，并将立即受益于17个项目在福赛斯。根据研究中使用的成像技术类型，这些项目可以分为许多大类：（1）使用CLSM生成的图像研究口腔生物膜的形成、生物膜与上皮细胞的相互作用以及对生物膜的免疫反应;（2）利用原位杂交和共聚焦激光扫描显微镜（CLSM）定位基因表达;（3）利用数字微阵列高通量筛选口腔细菌基因的全局表达;（4）使用荧光成像系统（STORM 840）和CLSM的光学切片能力研究特定基因和蛋白质表达;和（5）通过使用CLSM和微型CT定位破骨细胞中的基因表达、蛋白质加工和分子相互作用来研究骨吸收中的基因调控机制。福赛斯研究所保证提供：（1）在计算和网络技术办公室为支持西姆斯应用程序所需的额外服务器硬件提供住房;（2）安装和最终用户培训费用;（3）软件实施期间的现场咨询;（4）为福赛斯的数据库管理员提供甲骨文培训;（5）西姆斯应用程序和Oracle 9 i数据库软件的年度软件维护，以及（6）永久性内部支持。