Clarifying the pathogenic role of arousal-hyperventilation in obstructive and central sleep apnoea: Testing fundamental pathophysiological mechanisms and a strategic new treatment

阐明觉醒过度通气在阻塞性和中枢性睡眠呼吸暂停中的致病作用：测试基本病理生理机制和战略性新治疗方法

• 批准号: nhmrc : GNT1078749
• 负责人: Prof Karen Reynolds
• 金额: $ 40.26万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/clarifying-pathogenic-role-new-treatment/1345234
• 关键词: Clarifying; pathogenic; role; arousal; hyperventilation

This project is designed to understand the mechanisms underpinning much more stable breathing during deep sleep in obstructive sleep apnoea (OSA). A newly developed analytical technique will be used to examine breathing effort changes across sleep, and interactions with respiratory-induced awakenings in OSA patients. In addition, a new treatment designed to stabilise breathing will be tested and refined towards a new treatment option for OSA and for central sleep apnoea.

该项目旨在了解阻塞性睡眠呼吸暂停（OSA）患者在深度睡眠期间更稳定呼吸的机制。一种新开发的分析技术将用于检查睡眠中呼吸努力的变化，以及OSA患者与睡眠诱导觉醒的相互作用。此外，一种旨在稳定呼吸的新治疗方法将被测试和完善，以成为OSA和中枢性睡眠呼吸暂停的新治疗选择。