Clarifying the pathogenic role of arousal-hyperventilation in obstructive and central sleep apnoea: Testing fundamental pathophysiological mechanisms and a strategic new treatment

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This project is designed to understand the mechanisms underpinning much more stable breathing during deep sleep in obstructive sleep apnoea (OSA). A newly developed analytical technique will be used to examine breathing effort changes across sleep, and interactions with respiratory-induced awakenings in OSA patients. In addition, a new treatment designed to stabilise breathing will be tested and refined towards a new treatment option for OSA and for central sleep apnoea.