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A New Iron Age: Atom efficient P-C bond forming reactions with simple, designed iron catalysts

新铁器时代：使用简单设计的铁催化剂进行原子效率高的 P-C 键形成反应

基本信息

批准号：
EP/M019810/1
负责人：
Ruth Webster
金额：
$ 12.6万
依托单位：
University of Bath
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2015
资助国家：
英国
起止时间：
2015 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FM019810%2F1
关键词：
New Iron Age Atom efficient

项目摘要

Catalysis is the process by which chemical reactions are made to run faster at lower temperature. The vast majority of chemical industries rely on developing catalysis therefore making vital industrial processes, fundamental to the pharmaceutical, agrochemical and fine chemical industries, easier and more cost efficient. Catalysis allows us to precisely modify chemical structure through the ability to make and break specific chemical bonds. Catalyst design is therefore an incredibly important and vital undertaking: the key to unlocking new reactivity and new bond forming methods.This project looks into the design of catalysts which contain staggeringly simple motifs along with abundant and inexpensive iron centre. Iron is also biocompatible and non-toxic providing a strong foundation for our targeted reaction: hydrophosphination. These reactions allow the synthesis of carbon-phosphorus bonds using efficient reaction conditions, forming key motifs or new architectures with ease. The preparation of phosphorus-containing motifs cannot be underestimated, allowing the preparation of new ligands, organocatalysts and biologically relevant motifs vital to a host of crucial manufacturing sectors. Beyond this we will develop this carbon-phosphorus bond forming chemistry for the preparation of new building blocks to construct non-burning plastics (high value materials used in advanced electronic devices and as commodity chemicals in the flame retardants industries).The aim: * Investigate their potential in 100% atom-economic processes which make molecules relevant to the pharmaceutical and agrochemical industries. * Generate high value chemicals by developing a new route to the building blocks for phosphorus-containing plastics; this new route gives access to new plastics.

催化是使化学反应在较低温度下进行得更快的过程。绝大多数化学工业依赖于开发催化剂，因此使制药，农用化学品和精细化学品工业的重要工业过程变得更容易，更具成本效益。催化使我们能够通过建立和破坏特定化学键的能力来精确地修改化学结构。因此，催化剂设计是一项极其重要和至关重要的工作：开启新的反应性和新的键形成方法的关键。该项目研究了催化剂的设计，这些催化剂包含惊人简单的图案沿着丰富而廉价的铁中心。铁也是生物相容性和无毒的，为我们的靶向反应提供了坚实的基础：氢膦化。这些反应允许使用有效的反应条件合成碳-磷键，轻松形成关键图案或新结构。不能低估含磷基序的制备，这使得新配体、有机催化剂和生物相关基序的制备对许多关键制造业至关重要。除此之外，我们还将开发这种碳-磷键形成化学，用于制备新的结构单元，以构建不燃烧的塑料（用于先进电子设备的高价值材料和阻燃剂行业的商品化学品）。目的：* 研究它们在100%原子经济过程中的潜力，使分子与制药和农业化学工业相关。* 通过开发含磷塑料构建模块的新途径来生产高价值化学品;这一新途径提供了获得新塑料的途径。