Material Properties of the Intervertebral Disc

椎间盘的材料特性

• 批准号: EP/M022242/1
• 负责人: Spyros Masouros
• 金额: $ 12.54万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FM022242%2F1
• 关键词: Material; Properties; Intervertebral; Disc

The intervertebral disc is the primary articulation between adjacent vertebral bodies in the human spine. Degenerative disc disease is the leading cause of pain and disability in the adult; replacing the diseased disc with an artificial material is becoming the treatment of choice in cases that require surgery. At the same time, injuries to the spinal column are common in incidents that are associated with high accelerations, such as falls, sports injuries, road traffic accidents, and acts of violence; these injuries are often associated with long term disability. Injury induced by road-traffic accidents alone is predicted to become the third leading cause for burden of disease by 2030 according to the World Health Organization. A comprehensive understanding of the mechanisms associated with injury to the spine is lacking, especially in high-energy trauma. Official NATO reports acknowledge the limitations of current injury criteria and lack of injury risk curves for the spine; these criteria and curves would allow us to evaluate vehicles and protection systems appropriately. Similarly, the human-like response of anthropometric test devices (or dummies) in predicting the response of the human spine under load is questionable. As a result, strategies to enhance protection and to improve protective equipment are being developed using sub-standard technologies. Finite element (FE) modelling - a type of computer simulation of the mechanics of structures - of human injury, of implants and of protective systems are important engineering tools that allow us to understand the mechanisms involved in an injurious event and to develop new and improved evaluation criteria, techniques, materials and designs in a cost-efficient manner. As computational power becomes more abundant, FE modelling for optimal design is a clear strategic direction in industry as an alternative to expensive and labour intensive experiments. A critical parameter, however, that influences the predictive ability of FE models of human response is the quality of the input data that are associated with the material behaviour of human tissue. Such data, particularly at loading rates relevant to injury, are sparse for most human tissues; this is definitely the case for the intervertebral disc. The aim of this project, therefore, is to quantify the material behaviour of the human intervertebral disc across physiological and injurious loading rates. The intention is to inform implant design and to increase the accuracy of FE models of human injury in order to improve their ability to simulate the response of the spine under load.

椎间盘是人体脊柱中相邻椎体之间的主要关节。退行性椎间盘疾病是成人疼痛和残疾的主要原因;在需要手术的情况下，用人工材料替换患病的椎间盘正在成为治疗的选择。同时，脊柱损伤在与高加速度相关的事件中很常见，例如福尔斯、运动损伤、道路交通事故和暴力行为;这些损伤通常与长期残疾相关。据世界卫生组织预测，到2030年，仅道路交通事故造成的伤害就将成为疾病负担的第三大原因。对脊柱损伤相关机制缺乏全面的了解，特别是在高能量创伤中。北约官方报告承认目前的损伤标准的局限性和缺乏脊柱损伤风险曲线;这些标准和曲线将使我们能够适当地评估车辆和保护系统。同样，人体测量测试装置（或假人）在预测人体脊柱在负荷下的响应时的类人响应也是值得怀疑的。因此，正在利用低于标准的技术制定加强保护和改进保护设备的战略。有限元（FE）建模-一种结构力学的计算机模拟-人体损伤，植入物和保护系统是重要的工程工具，使我们能够了解伤害事件中涉及的机制，并以具有成本效益的方式开发新的和改进的评估标准，技术，材料和设计。随着计算能力变得越来越丰富，有限元建模优化设计是一个明确的战略方向，在工业中作为一种替代昂贵的和劳动密集型的实验。然而，一个关键的参数，影响人体响应的FE模型的预测能力是与人体组织的材料行为相关联的输入数据的质量。这样的数据，特别是在与损伤相关的加载速率下，对于大多数人体组织来说是稀疏的;对于椎间盘来说绝对是这样。因此，本项目的目的是量化人体椎间盘在生理和损伤负荷率下的材料行为。其目的是为植入物设计提供信息，并提高人体损伤有限元模型的准确性，以提高其模拟脊柱在载荷下反应的能力。

项目成果

Spinal Injury

脊柱损伤

• DOI: 10.21820/23987073.2017.2.78
• 发表时间: 2017
• 期刊: Impact
• 作者: Masouros S

The Effect of Degeneration on Internal Strains and the Mechanism of Failure in Human Intervertebral Discs Analyzed Using Digital Volume Correlation (DVC) and Ultra-High Field MRI.

使用数字体积相关（DVC）和超高场MRI分析的人椎间盘中的变性对内部菌株的影响和失败机制。

• DOI: 10.3389/fbioe.2020.610907
• 发表时间: 2020
• 期刊: Frontiers in bioengineering and biotechnology
• 影响因子: 5.7
• 作者: Tavana S;Masouros SD;Baxan N;Freedman BA;Hansen UN;Newell N
• 通讯作者: Newell N

Multiscale Validation of Multiple Human Body Model Functional Spinal Units.

多个人体模型功能性脊柱单位的多尺度验证。

• DOI: 10.1115/1.4049332
• 发表时间: 2021
• 期刊: Journal of biomechanical engineering
• 作者: Draper D