Time Varying Modulators of Spine Injury Mechanics and Material Properties of Collagen and the Intervertebral Disc
脊柱损伤力学和胶原蛋白和椎间盘材料特性的时变调制器
基本信息
- 批准号:RGPIN-2022-03335
- 负责人:
- 金额:$ 6.63万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2022
- 资助国家:加拿大
- 起止时间:2022-01-01 至 2023-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The prevalence of sedentary and light activity occupations has increased 100% over the past five decades. These prolonged common physical exposures have been linked to the reporting of low back pain. To give context for the impact of low back pain, it is one of the top three occupational lost time problems, affects approximately 80% of the population, and has the longest number of years lived with a disability. Exposure to sedentary tasks impacts the mechanical response of the lumbar spine, attributed to spine flexion straining posterior tissues in sitting and extension compressing the intervertebral disc and facet joints in standing. These postures directly impact pain sensitivity and lumbar spine stiffness. During chronic physical exposures, the intervertebral disc of the spine can become disrupted with the cartilaginous endplate identified as the structure where the cascade of mechanical failure is initiated in the majority of disc herniations. A solid understanding of the injury mechanisms associated with mechanical loading is crucial for injury prevention. The biological repair mechanisms in the intervertebral disc are slower than the injury process, in part due to the lack of blood supply to this structure. Accordingly, examination of the microstructural initiation of damage is critical to minimize risk of tissue injury and future progression to low back pain. The overall direction of my research program investigates time-varying lumbar spine changes in response to prolonged mechanical loading to understand how these changes impact injury initiation, progression, and nociception. The causes of injury initiation and progression of the intervertebral disc structure of the spine due to chronic exposure will be investigated. Studies examining the demands on the low back of individuals when performing sedentary tasks, representing sitting and standing office computer or light assembly work, will be combined with investigations at the tissue level. An assessment of time-dependent stiffness and loading variability responses of spinal tissues will determine the resulting damage potential. The proposed studies will directly assess, at a tissue level, if sedentary prolonged exposures create a microstructural damage pathway for lumbar spine injury that could explain the link between sedentary tasks and low back pain. The outcomes from this research will provide time-dependent material properties that are linked to the initiation of spine damage at a microstructural level. Ultimately, the linking of chronic exposure with potential injury initiation would be a powerful and novel fundamental contribution in developing methods to assess daily loading and set sedentary exposure standards to prevent injuries. This work will provide knowledge of the underlying healthy tissue response in the low back, laying a foundation to develop usage guidelines for occupational workstations involving sit and stand components.
在过去的五十年里,久坐不动和轻度活动职业的流行率增加了100%。这些长时间的常见身体暴露与腰痛的报告有关。为了说明腰痛的影响,它是三大职业损失时间问题之一,影响大约80%的人口,并且具有最长的残疾年数。暴露于久坐任务影响腰椎的机械反应,这归因于在坐姿时脊柱屈曲使后部组织紧张,以及在站立时伸展压缩椎间盘和小关节。这些姿势直接影响疼痛敏感性和腰椎硬度。在慢性物理暴露过程中,脊柱椎间盘可能被软骨终板破坏,软骨终板被认为是大多数椎间盘突出中引发一连串机械故障的结构。深入了解与机械负荷相关的损伤机制对于预防损伤至关重要。椎间盘中的生物修复机制比损伤过程慢,部分原因是该结构缺乏血液供应。因此,检查损伤的微结构起始对于最小化组织损伤和未来进展为腰痛的风险至关重要。我的研究项目的总体方向调查了随时间变化的腰椎变化,以响应长期的机械负荷,以了解这些变化如何影响损伤的发生,进展和伤害感受。将研究由于长期暴露导致脊柱椎间盘结构损伤开始和进展的原因。研究检查的要求下背部的个人时,执行久坐不动的任务,代表坐着和站立的办公室电脑或轻装配工作,将结合调查在组织水平。对脊柱组织随时间变化的刚度和载荷变化反应的评估将确定所产生的损伤潜力。拟议的研究将在组织水平上直接评估久坐不动的长期暴露是否会造成腰椎损伤的微观结构损伤途径,这可能解释久坐不动的任务与腰痛之间的联系。这项研究的结果将提供与微结构水平上脊柱损伤开始相关的时间依赖性材料特性。最终,慢性暴露与潜在的损伤启动的联系将是一个强大的和新颖的基本贡献,在开发方法,以评估日常负荷和设定久坐暴露标准,以防止伤害。这项工作将提供下背部潜在健康组织反应的知识,为制定涉及坐立组件的职业工作站使用指南奠定基础。
项目成果
期刊论文数量(0)
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Callaghan, Jack其他文献
The effect of task type and perceived demands on postural movements during standing work
- DOI:
10.1016/j.apergo.2018.01.015 - 发表时间:
2018-05-01 - 期刊:
- 影响因子:3.2
- 作者:
Glinka, Michal;Metzger, Sabrina;Callaghan, Jack - 通讯作者:
Callaghan, Jack
The impact of office chair features on lumbar lordosis, intervertebral joint and sacral tilt angles: a radiographic assessment
- DOI:
10.1080/00140139.2016.1265670 - 发表时间:
2017-01-01 - 期刊:
- 影响因子:2.4
- 作者:
De Carvalho, Diana;Grondin, Diane;Callaghan, Jack - 通讯作者:
Callaghan, Jack
Callaghan, Jack的其他文献
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{{ truncateString('Callaghan, Jack', 18)}}的其他基金
Spine Biomechanics and Injury Prevention
脊柱生物力学和损伤预防
- 批准号:
CRC-2018-00054 - 财政年份:2022
- 资助金额:
$ 6.63万 - 项目类别:
Canada Research Chairs
Time-Varying Material Properties of the Intervertebral Disc and the Influence on Spine Joint Mechanics
椎间盘时变材料特性及其对脊柱关节力学的影响
- 批准号:
RGPIN-2016-04136 - 财政年份:2021
- 资助金额:
$ 6.63万 - 项目类别:
Discovery Grants Program - Individual
Spine Biomechanics And Injury Prevention
脊柱生物力学和损伤预防
- 批准号:
CRC-2018-00054 - 财政年份:2021
- 资助金额:
$ 6.63万 - 项目类别:
Canada Research Chairs
Time-Varying Material Properties of the Intervertebral Disc and the Influence on Spine Joint Mechanics
椎间盘时变材料特性及其对脊柱关节力学的影响
- 批准号:
RGPIN-2016-04136 - 财政年份:2020
- 资助金额:
$ 6.63万 - 项目类别:
Discovery Grants Program - Individual
Spine Biomechanics and Injury Prevention
脊柱生物力学和损伤预防
- 批准号:
CRC-2018-00054 - 财政年份:2020
- 资助金额:
$ 6.63万 - 项目类别:
Canada Research Chairs
Spine Biomechanics and Injury Prevention
脊柱生物力学和损伤预防
- 批准号:
CRC-2018-00054 - 财政年份:2019
- 资助金额:
$ 6.63万 - 项目类别:
Canada Research Chairs
Time-Varying Material Properties of the Intervertebral Disc and the Influence on Spine Joint Mechanics
椎间盘时变材料特性及其对脊柱关节力学的影响
- 批准号:
RGPIN-2016-04136 - 财政年份:2019
- 资助金额:
$ 6.63万 - 项目类别:
Discovery Grants Program - Individual
Time-Varying Material Properties of the Intervertebral Disc and the Influence on Spine Joint Mechanics
椎间盘时变材料特性及其对脊柱关节力学的影响
- 批准号:
RGPIN-2016-04136 - 财政年份:2018
- 资助金额:
$ 6.63万 - 项目类别:
Discovery Grants Program - Individual
Spine Biomechanics and Injury Prevention
脊柱生物力学和损伤预防
- 批准号:
1000228146-2011 - 财政年份:2018
- 资助金额:
$ 6.63万 - 项目类别:
Canada Research Chairs
Objectively Defining Design Parameters Associated with Automotive Seat Comfort
客观定义与汽车座椅舒适度相关的设计参数
- 批准号:
533393-2018 - 财政年份:2018
- 资助金额:
$ 6.63万 - 项目类别:
Engage Grants Program
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