AUGMENTED PROTEIN TRANSPORT IN SHEARED SUSPENSIONS

剪切悬浮液中增强的蛋白质运输

• 批准号: 3471816
• 负责人: RICHARD L BEISSINGER
• 金额: $ 10.83万
• 依托单位: ILLINOIS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-05-01 至 1994-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3471816
• 关键词: albumins; blood proteins; erythrocyte membrane; fibrinogen; fluorescence; gamma globulin; liposomes; macromolecule; mathematical model; nonblood rheology; particle; protein transport; solutions; suspensions; viscosity

This research program attempts to improve the current understanding of the transport phenomena of macromolecular solutes in sheared suspensions undergoing laminar flow. Using the technique of internal reflection fluorescence (IRF), augmented mass transfer will be determined using a rotating disc flow system. The diffusion coefficients of several macromolecular solutes will be measured in aqueous suspensions as a function of suspension particle volume fraction, shear rate, suspension viscosity/viscoelasticity, particle size, particle rigidity, and shear rate. This proposal intends to identify and characterize the important experimental parameters and to clarify mechanisms involved in enhancing the diffusivities of macromolecular solutes in sheared suspensions.

这项研究计划试图提高目前对 大分子溶质在剪切过程中的输运现象 处于层流状态的悬浮液。使用的技术 内反射荧光(IRF)增强传质 将使用旋转圆盘流动系统来确定。 几种大分子溶质的扩散系数将 在含水悬浮液中作为悬浮液的函数进行测量 颗粒体积分数、剪切速率、悬浮液 粘度/粘弹性、颗粒大小、颗粒 刚性和剪切率。这项提案意在确定和 描述重要的实验参数，并澄清 增强细菌扩散系数的机制 剪切悬浮液中的大分子溶质。