剪切悬浮液中增强的蛋白质运输-猫眼课题宝

剪切悬浮液中增强的蛋白质运输

批准号：

3471815

负责人：

RICHARD L BEISSINGER

金额：

$10.63万

依托单位：

ILLINOIS INSTITUTE OF TECHNOLOGY

依托单位国家：

美国

项目类别：

财政年份：

1989

资助国家：

美国

项目状态：

已结题

起止时间：

1989-05-01 至 1994-04-30

来源：

https://reporter.nih.gov/project-details/3471815

关键词：

albumins blood proteins erythrocyte membrane fibrinogen fluorescence gamma globulin liposomes macromolecule mathematical model nonblood rheology particle protein transport solutions suspensions viscosity

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英文摘要

This research program attempts to improve the current understanding of the transport phenomena of macromolecular solutes in sheared suspensions undergoing laminar flow. Using the technique of internal reflection fluorescence (IRF), augmented mass transfer will be determined using a rotating disc flow system. The diffusion coefficients of several macromolecular solutes will be measured in aqueous suspensions as a function of suspension particle volume fraction, shear rate, suspension viscosity/viscoelasticity, particle size, particle rigidity, and shear rate. This proposal intends to identify and characterize the important experimental parameters and to clarify mechanisms involved in enhancing the diffusivities of macromolecular solutes in sheared suspensions.

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