PHYSIOLOGICAL AND BEHAVIORAL CORRELATES OF INFANT COLIC

婴儿绞痛或长时间的，无法安慰的哭泣， 婴儿一直是父母和儿科医生困惑的根源。 这在很大程度上是由于缺乏关于其起源的具体证据。 更令人困惑的是，绞痛可能会影响 后来的婴儿行为或父母对这种行为的看法。 目的 拟议研究的一个目的是通过调查 婴儿绞痛的生理和行为前因和相关因素， 来研究它对婴儿后期发育的影响。 为了达到这些目的， 建议进行两项研究。 一个是纵向研究， 前瞻性地识别并随访一组绞痛和非绞痛婴儿 从出生到十个月大。 另外两组，一组易怒 经常哭泣但不符合绞痛标准的人，以及 表现出过度的胃肠道症状，但不会过度哭闹 也要遵循。 绞痛的出现将在发作时被识别 以及通过日记获得的与绞痛相关的行为。 轶事报告和我们对在这期间表现出的行为的初步研究 绞痛发作表明婴儿表现出胃肠道疼痛。 使用非侵入性胃电图（EGG）对成年人进行的研究表明， 报告胃肠道不适与心律失常相关。 我们 建议记录基线和肠绞痛期间肠绞痛婴儿的EGG 确定正常节律变化是否与 有绞痛性哭泣的行为 确定婴儿的贡献 气质对绞痛的发生和绞痛是否影响婴儿 一旦它消失了，我们建议测量婴儿的反应性， 在出生、5个月和10个月大时， 实验室程序和父母评级。 第二个横断面研究 提出了检查胃肌电活动的发展 在生命的第一年使用EGG。 到目前为止，没有发展 存在使用该测量的研究。 这项研究将在纵向 研究的结果是必不可少的，我们的理解 与绞痛相关的生理变化。 这两项研究将有助于 对婴儿健康和发育的几个领域提供重要信息。

Infant colic or prolonged, inconsolable crying in an otherwise healthy infant has been a source of confusion for parents and pediatricians alike. Much of this is due to the lack of concrete evidence as to its origins. Adding to the confusion is the finding that colic may have an impact on later infant behavior or parent perceptions of that behavior. The purpose of the proposed research is to address these issues by investigating the physiological and behavioral antecedents and correlates of infant colic and to examine its influences on later infant development. Toward these ends, two studies are proposed. One is a longitudinal study designed to prospectively identify and follow a group of colic and non-colic infants from birth to ten months of age. Two other groups, one an irritable group that cries frequently but does not meet colic criteria, and one that exhibits excessive gastrointestinal symptoms but not excessive crying will also be followed. The emergence of colic will be identified at its onset and behaviors associated with colic obtained through the use of diaries. Anecdotal reports and our preliminary study of behaviors exhibited during a colic bout suggest that infants are expressing gastrointestinal pain. Work with adults using the non-invasive electrogastrogram (EGG) has shown reports of gastrointestinal upset to be associated with dysrhythmia. We propose to record the EGGs of colic infants during a baseline and colic condition to determine whether changes in normal rhythms are associated with colic cry behavior. To determine the contribution of infant temperament to the emergence of colic and whether colic influences infant behavior once it has dissipated, we propose to measure infant reactivity and regulation at birth, five months, and 10 months of age through laboratory procedures and parental ratings. A second cross-sectional study is proposed to examine the development of gastric myoelectric activity within the first year of life using the EGG. To date, no developmental studies using this measure exist. This study will precede the longitudinal study as the results are essential to our understanding of the physiological changes associated with colic. Both studies will contribute important information to several areas of infant health and development.