Mechanisms that mediate the link between lead exposure and child behavior problem

介导铅暴露与儿童行为问题之间联系的机制

• 批准号: 8660694
• 负责人: JIANGHONG LIU
• 金额: $ 13.12万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8660694
• 关键词: Accounting; Achievement; Adolescent; Adult; Affect; Affective; Age; Aggressive behavior; Attention deficit hyperactivity disorder; Award; Behavior; Behavioral; Biosocial; Brain; Centers for Disease Control and Prevention (U.S.); Child; Child Behavior; Childhood; Clinical; Cognitive; Cognitive deficits; Cohort Studies; Communities; Competence; Cross-Sectional Studies; Data; Development; Developmental Process; Dietary Intervention; Dietary Supplementation; Disease; Effectiveness; Emotional; Environment; Family; Fostering; Functional disorder; Funding; Future; Galvanic Skin Response; Goals; Impaired cognition; Impairment; Independent Scientist Award; Individual; Interdisciplinary Study; International; Knowledge; Lead; Link; Long-Term Effects; Measurement; Mediating; Mediator of activation protein; Metals; National Institute of Environmental Health Sciences; Neurobiology; Neurocognitive; Neurotoxins; Nursery Schools; Omega-3 Fatty Acids; Outcome; P300 Event-Related Potentials; Parenting behavior; Performance; Prevention; Prevention strategy; Preventive Intervention; Problem behavior; Procedures; Process; Psychopathology; Psychophysiology; Public Health; Quality of life; Relative (related person); Research; Research Personnel; Research Project Grants; Risk; Risk Factors; Sampling; Schools; Scientist; Senior Scientist; Statistical Models; Stress; Supplementation; Testing; Time; Toxic Environmental Substances; Toxic effect; Training; Translating; Translational Research; United States National Institutes of Health; Violence; base; blood lead; career development; clinical practice; conditioned fear; early adolescence; experience; externalizing behavior; improved; lead exposure; neurobiological mechanism; neurotoxic; preadolescence; prevent; programs; prospective; psychosocial; research and development; skills; social; theories

DESCRIPTION (provided by applicant) We currently lack knowledge on the intermediary mechanisms whereby lead exposure translates itself into increased behavior problems in childhood. This K02 Independent Scientist Development Award application will enable the candidate to develop an interdisciplinary program of research whose overarching goal is to uncover the cognitive and affective mechanisms of action underlying lead exposure-behavior problems relationship in a large sample of community children. This research program questions the current CDC "safe" standard of 10 ug/dl of lead, and hypothesizes that early sub-clinical lead exposure results in negative clinical, cognitive, and affective functioning. Building on an NIEHS-funded community preschool cohort study, the investigators will first propose to repeat measurements of both blood lead levels and behavioral outcomes to assess whether children with sustained sub-clinical blood lead levels across time are especially likely to develop externalizing behavior problems. Second, the investigators aim to understand how lead exposure interacts with social risk factors in predisposing to externalizing behavior problems. Third, and importantly, they propose to elucidate the neurocognitive and affective mediating mechanisms by which lead exposure during the preschool years contribute to externalizing behavior problems in early adolescence. This K02 will help foster the candidate's ability to achieve these research goals by providing her with protected time to collaborate more closely with senior scientists in the field, to be more fully engaged in her NIH- funded international research project on this sample, and to enhance her interdisciplinary knowledge and skills in development psychopathology, environmental toxicity, psycho-physiological testing, and advanced statistical analysis. Programmatically, the K02 will be of critical value in moving her into a new line of interdisciplinary research on prevention and intervention of behavior problems by giving her time to develop a nutritional intervention for preventing and treating behavior problems in lead-exposed children. This research program consequently has the potential to help redefine what level of lead exposure is safe, identify hitherto unknown mechanisms of action, and reduce childhood behavior problems throughout the community.

描述(由申请人提供) 我们目前缺乏关于铅暴露本身转化为儿童行为问题增加的中介机制的知识。K02独立科学家发展奖的申请将使候选人能够开发一个跨学科的研究计划，其总体目标是在大样本社区儿童中揭示潜在的铅暴露-行为问题关系的认知和情感行动机制。这项研究计划质疑疾控中心现行的10微克/分升铅的安全标准，并假设早期亚临床铅暴露会导致负面的临床、认知和情感功能。在NIEHS资助的一项社区学龄前队列研究的基础上，研究人员将首先提议重复测量血铅水平和行为结果，以评估随着时间的推移，血铅水平持续处于亚临床水平的儿童是否特别有可能出现外在行为问题。其次，研究人员的目标是了解铅暴露如何与社会风险因素相互作用，导致行为问题外部化。第三，也是重要的一点，他们建议阐明神经认知和情感调节机制，通过这些机制，学龄前几年的铅暴露有助于在青春期早期外化行为问题。K02将帮助培养候选人实现这些研究目标的能力，为她提供受保护的时间，让她与该领域的资深科学家更紧密地合作，更全面地参与她由NIH资助的关于该样本的国际研究项目，并增强她在发展、精神病理学、环境毒性、心理生理测试和高级统计分析方面的跨学科知识和技能。从程序上讲，K02将为她提供时间开发一种预防和治疗铅暴露儿童行为问题的营养干预方法，从而将她带入行为问题预防和干预的新的跨学科研究领域，具有关键价值。因此，这项研究计划有可能帮助重新定义什么水平的铅暴露是安全的，确定迄今未知的作用机制，并减少整个社区的儿童行为问题。