In utero Assessment of the Human Neural Connectome and Later Child Behavior

人类神经连接组和后期儿童行为的子宫内评估

• 批准号: 9170791
• 负责人: Moriah E Thomason
• 金额: $ 52.15万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-15 至 2021-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9170791
• 关键词: 4 year old; Achievement; Age; Anatomy; Attention; Award; Behavior; Behavioral; Biological Neural Networks; Biology; Birth; Boxing; Brain; Characteristics; Child; Child Behavior; Childhood; Cognitive; Complex; Cross-Sectional Studies; Data; Development; Developmental Process; Disease; Disease Pathway; Dorsal; Early Diagnosis; Environment; Etiology; Evaluation; Exhibits; Fetus; Foundations; Functional Magnetic Resonance Imaging; Future; Gestational Age; Goals; Graph; Health; Human; Image; Income; Individual; Infant; Informal Social Control; Knowledge; Length; Life; Long-Term Effects; Longevity; Longitudinal Studies; Magnetic Resonance Imaging; Maps; Measures; Mediating; Mental Health; Mental disorders; Mothers; National Institute of Mental Health; Nervous system structure; Neurobiology; Neurocognitive; Neurologic; Neurosciences; Neurosciences Research; Outcome; Participant; Pathway interactions; Pattern; Performance; Perinatal Exposure; Physiological; Pregnancy; Pregnant Women; Prevention; Protocols documentation; Psychopathology; Recruitment Activity; Research; Research Personnel; Rest; Risk; Sampling; Services; Sex Education; Staging; Techniques; Technology; Testing; Time; Uterus; Variant; Woman; Work; base; behavioral health; brain morphology; career; cognitive control; connectome; developmental disease; disorder prevention; early childhood; fetal; high risk; improved; in utero; innovation; life-long learning; maternal stress; nerve stem cell; nervous system disorder; neurobehavioral; neuroimaging; neuropsychiatric disorder; novel; operation; postnatal; prenatal; prenatal stress; prevent; prospective; psychologic; relating to nervous system

PROJECT SUMMARY The human fetal brain is complex, highly plastic, and extremely vulnerable. Mild variation in utero can drastically impair life-long learning and neurological health. Despite growing appreciation for the relevance of this period to numerous developmental, psychiatric and neurological disorders, macroscale functional organization of the fetal brain remains a `black box' for neuroscience research. While there are phenomenal technologies for examining fetal brain anatomy, only very recently have we possessed non-invasive means of studying coordinated function in the living human fetal brain. This project is focused on understanding the emergence of whole brain functional circuitry beginning in fetal life, and identifying relationships between prenatal brain connectivity and preschoolers' attainment of key developmental milestones. Given that the womb is the first environment for the fetus, and is thus the place where biology and environment first interact, we will also examine the effects of prenatal stress exposure on human fetal brain functional connectivity. Sixty women will be recruited in weeks 25-32 of pregnancy and entered into a longitudinal functional magnetic resonance imaging (MRI) protocol. Brain resting-state functional connectivity (RSFC) MRI data will be obtained 3x longitudinally prior to and following birth, spanning ages 25 weeks gestational age to 12 weeks postnatal age. Discoveries about network emergence in this first step will provide a basis for subsequent evaluation of the relationship between brain maturation in utero and attainment of developmental milestones in childhood. To this end, self-regulatory behavior will then be measured in an existing sample of 110 preschoolers that underwent fetal brain RSFC imaging 4 years ago. In these participants, associations between maternal prenatal stress, fetal brain functional connectivity, and child neurobehavioral development will be examined. The primary aims of this project are to (i) break new ground in our understanding of the emergence of whole brain functional circuitry beginning in fetal life, (ii) identify variations in prenatal brain connectivity that may predispose 4-year-old children to delayed attainment of key developmental milestones that prognosticate life long health, and (iii) examine the influence of prenatal stress on emergent fetal brain functional connectivity. With its innovative focus on precursors, vulnerability, and consequences of fetal RSFC, this project is ideally suited to the NIMH BRAINS award aiming to support a productive early stage investigator in the implementation of high-impact, novel research. Initiation and achievement of these research aims will be the first step in a career focused on identifying neurobiological pathways through which early developmental risk may be conferred and also ultimately prevented.

项目概要 人类胎儿的大脑非常复杂，可塑性很强，而且极其脆弱。子宫内的轻微变异可以 严重损害终身学习和神经健康。尽管人们越来越认识到 这一时期出现了许多发育、精神和神经系统疾病、宏观功能障碍 胎儿大脑的组织仍然是神经科学研究的“黑匣子”。虽然有现象级的 检查胎儿大脑解剖结构的技术，直到最近我们才拥有了非侵入性手段 研究活人胎儿大脑的协调功能。该项目的重点是了解 从胎儿生命开始，整个大脑功能回路的出现，并确定之间的关系 产前大脑连接和学龄前儿童实现关键发展里程碑。鉴于 子宫是胎儿的第一个环境，因此是生物和环境首先相互作用的地方， 我们还将研究产前压力暴露对人类胎儿大脑功能连接的影响。六十 女性将在怀孕 25-32 周被招募，并进入纵向功能磁 磁共振成像 (MRI) 协议。将获得大脑静息态功能连接 (RSFC) MRI 数据 出生前和出生后纵向 3 倍，跨越孕周 25 周至产后 12 周 年龄。第一步关于网络出现的发现将为后续评估提供基础 子宫内大脑成熟与儿童期发育里程碑的实现之间的关系。 为此，我们将在现有的 110 名学龄前儿童样本中测量自我监管行为， 4 年前接受了胎儿脑部 RSFC 成像。在这些参与者中，母亲之间的关联 将检查产前压力、胎儿大脑功能连接和儿童神经行为发育。 该项目的主要目标是（i）在我们对整体出现的理解上开辟新天地 从胎儿生命开始的大脑功能回路，（ii）识别产前大脑连接的变化，这些变化可能 使 4 岁儿童容易延迟实现预测生命的关键发育里程碑 长期健康，(iii) 检查产前压力对胎儿大脑功能连接的影响。 由于其创新性地关注胎儿 RSFC 的前兆、脆弱性和后果，该项目非常理想 适合 NIMH BRAINS 奖，旨在支持富有成效的早期研究人员 实施高影响力的新颖研究。这些研究目标的启动和实现将是 职业生涯的第一步专注于识别早期发育风险的神经生物学途径 可能会被授予，也可能最终会被阻止。