ANTIGEN-PROCESSING AND T CELL REPERTOIRE

1.确定与处理有关的关键事件 蛋白抗原，由此膜相关蛋白 能够与表面MHC特异相互作用的片段 分子是由可溶的天然抗原产生的。 2.识别导致耐受性诱导的信号 而不是克隆扩增，当自体抗原偶联时 自身MHC分子与胸腺或胸腺中的T细胞结合 文化。 3.研究免疫球蛋白可变区在糖尿病发病中的作用 分化和分化过程中T细胞谱系的选择 免疫以及这一现象的机制。 4.在小鼠模型中，探索普乐可复的作用 用抗TAP抗体在体内激活T细胞，或用 抗TAP和抗肿瘤抗体的结合物对排斥反应的影响 实验性肿瘤，期望激活的杀手 在这一过程中，细胞将被特异性地定向到肿瘤靶点 模特。

1. To identify the critical events concerned with the processing of protein antigens, whereby membrane associated protein fragments capable of specific interaction with surface MHC molecules are generated from soluble native antigens. 2. To identify the signals which result in tolerance induction rather than clonal expansion, when autologous antigens coupled with self-MHC molecules are bound by T cells in the thymus or in culture. 3. To study the effects of immunoglobulin variable regions in the selection of the T cell repertoire during differentiation and immunization and the mechanism of this phenomenon. 4. To explore, in a murine model, the effects of the general activation of T cells, in vivo, with anti-TAP antibodies, or with conjugates of anti-TAP and anti-tumor antibodies on the rejection of experimental tumors, in the expectation that activated killer cells would be specifically directed to tumor targets in this model.