ANTIGEN PROCESSING AND T CELL REPERTOIRE

1. 识别与处理有关的关键事件 膜相关蛋白 能够与表面MHC特异性相互作用的片段 分子由可溶性天然抗原产生。 2. 识别导致耐受诱导的信号 而不是克隆扩增， 与自身MHC分子结合的T细胞在胸腺或 文化 3. 研究免疫球蛋白可变区在免疫细胞中的作用， 在分化过程中选择T细胞库， 免疫和这种现象的机制。 4. 为了在小鼠模型中探索一般的 在体内，用抗TAP抗体或用 抗TAP和抗肿瘤抗体的缀合物对排斥反应的影响 实验性肿瘤，期望激活的杀手 细胞将被特异性地定向到肿瘤靶点， 模型

1. To identify the critical events concerned with the processing of protein antigens, whereby membrane associated protein fragments capable of specific interaction with surface MHC molecules are generated from soluble native antigens. 2. To identify the signals which result in tolerance induction rather than clonal expansion, when autologous antigens coupled with self-MHC molecules are bound by T cells in the thymus or in culture. 3. To study the effects of immunoglobulin variable regions in the selection of the T cell repertoire during differentiation and immunization and the mechanism of this phenomenon. 4. To explore, in a murine model, the effects of the general activation of T cells, in vivo, with anti-TAP antibodies, or with conjugates of anti-TAP and anti-tumor antibodies on the rejection of experimental tumors, in the expectation that activated killer cells would be specifically directed to tumor targets in this model.