SOCIAL CONFLICT: IMMUNOLOGICAL & ENDOCRINOLOGICAL CONSEQ

“应激”在免疫调节中的作用 受到严密调查。然而，“压力”是一种高度的 含糊不清的术语和许多压力处理 实验室与压力很少或没有关系，如在 大自然。这项研究申请采用了新颖的方法 使用由激励性产生的生物相关应激 社会环境中老鼠之间的相遇和攻击性互动 冲突范式，以获得对机制和 控制应激诱导的调节的相互关系 免疫系统。免疫学实验的结果将形成 选择试验组的依据 内分泌分析，以确定假定重要的 内分泌调节免疫的途径。 免疫反应性将通过体内试验进行评估 以及体外使用特异性和非特异性免疫刺激剂， 流式细胞仪细胞分析及免疫调节测定 分子。内分泌分析将包括选择性的 内分泌功能的外科治疗、药物治疗和治疗 免疫中和技术。基于从以下方面获得的结果 如上所述，实验将专门测试 免疫系统和内分泌系统相互作用的程度 以应对社会冲突的压力。本研究设计 将允许直接因果关系 要检查的免疫和内分泌系统。因此，这是 一项提案旨在解决一种与生物相关的压力 可以调节免疫能力。此信息可能 因此适用于获得性免疫缺陷的研究 综合症(艾滋病)，因为有建议说进展 艾滋病可能在一定程度上依赖于 心理障碍引起的内分泌和免疫系统 受害者所经历的压力。

The role of "stress" in the modulation of immunity has recently come under intensive investigation. However, "stress" is a highly ambiguous term and many of the stress manipulations in the laboratory bear little or no relation to stress as encountered in nature. This research application takes the novel approach of using the biologically relevant stress resulting from agonistic encounters and aggressive interactions between mice in a social conflict paradigm to gain an understanding of the mechanisms and interrelationships governing stress induced modulation of the immune system. Results from immunological experiments will form the basis for selection of experimental groups to be used for endocrinological analysis in order to identify presumably important pathways of endocrine mediation of immunity. Immunological responsiveness will be assessed through the in vivo and in vitro use of specific and non-specific immune stimulants, flow cytometer cell analysis and measurement of immunoregulatory molecules. Endocrinological analysis will include selective ablation of endocrine function by surgical, pharmacological and immunoneutralization techniques. Based on results obtained from the above, experiments will be designed to specifically test the degree to which immunological and endocrinological systems interact in response to the stress of social conflict. This research design will thus allow for a direct cause and effect relationship between the immune and endocrine systems to be examined. As such, this proposal seeks to address whether a biologically relevant stress can modulate immunological competence. This information may therefore be applicable to the study of Acquired Immune Deficiency Syndrome (AIDS), since it has been suggested that the progression of AIDS may be dependent, in part, on altered interactions between the endocrine and immune systems resulting from the psychological stress that is experienced by its victims.