REFLEX ACTION OF MUSCLE CONTRACTION

肌肉收缩的反射动作

• 批准号: 3477063
• 负责人: RANDALL K POWERS
• 金额: $ 9.08万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-01-01 至 1993-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3477063
• 关键词: afferent nerve; cats; electromyography; electrostimulus; evoked potentials; histology; interneurons; muscle contraction; muscle tension; myofibrils; neural information processing; spinal cord; spinal nerves; spinal reflex; stimulus /response; stretch receptors

The momenttomoment control of movement depends both upon the descending commands to the spinal cord and on activity in spinal reflex pathways. Although the reflex actions of muscle stretch have been extensively studied, much less is known about the reflex actions of muscle stretch have been extensively studied, much less in known about the reflex actions of muscle contraction. In particular, there has been very little work on the neuronal mechanisms and functional role of reflex effects directed from the contracting muscle to other muscles. The purpose of the proposed research is to provide a quantitative analysis of these contractionevoked reflexes and to investigate their afferent and interneuronal mechanisms. This general goal can be divided into 3 specific aims: 1. To describe the pattern of reflex effects produced by muscle contraction in the decerebrate cat (with or without an additional partial spinal section). Reflex effects produced by isometric contractions (via ventral root stimulation), stretch, vibration and electrical stimulation of muscle nerves will be compared with the responses of different types of muscle afferents to determine the afferent source of these effects. 2. To describe the response of Group 1 and force activated interneurons to muscle contraction, stretch, vibration and nerve stimulation. Quantitative comparisons of reflex effects with afferent and interneuron response will be used to identify those interneurons most likely to mediate contractionevoked reflexes. 3. To determine the specific output connections of Group 1 and force activated interneurons by spiketriggered averaging from neuron discharge into electomyographic activity in various extensor muscles.

对运动的瞬间控制取决于 对脊髓的下行指令和对中枢神经系统的活动 脊椎反射路径。尽管肌肉的反射动作 伸展已经得到了广泛的研究，但对此知之甚少 肌肉拉伸的反射作用已被广泛研究。 研究过，对肌肉的反射行为知之甚少 收缩。特别是，在这方面的工作很少 反射效应的神经机制及其功能作用 从收缩的肌肉引导到其他肌肉。这个 拟议研究的目的是提供一种量化的 对这些收缩诱发反射的分析和研究 它们的传入和神经元间机制。这个总的目标是 具体目标可分为三个： 1.描述肌肉产生的反射效应的模式 去大脑猫的收缩(有或没有额外的 部分脊椎切片)。等轴测产生的反射效应 收缩(通过刺激前根)、伸展、振动和 电刺激肌肉神经将与 不同类型肌肉传入反应的研究 这些效应的传入来源。 2.描述第一组的反应和被激活的武力 中间神经元对肌肉收缩、伸展、振动和神经的作用 刺激。反射效应的定量比较 将使用传入和神经元间反应来识别这些 中间神经元最有可能介导收缩诱发的反射。 3.确定组1和组1的具体输出连接 压力激活的中间神经元通过触发平均 不同脑区神经元放电对肌电活动的影响 伸肌。