REFLEX ACTION OF MUSCLE CONTRACTION

肌肉收缩的反射动作

• 批准号: 3477060
• 负责人: RANDALL K POWERS
• 金额: $ 6.92万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-01-01 至 1992-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3477060
• 关键词: afferent nerve; cats; electromyography; electrostimulus; evoked potentials; histology; interneurons; muscle contraction; muscle tension; myofibrils; neural information processing; spinal cord; spinal nerves; spinal reflex; stimulus /response; stretch receptors

The momenttomoment control of movement depends both upon the descending commands to the spinal cord and on activity in spinal reflex pathways. Although the reflex actions of muscle stretch have been extensively studied, much less is known about the reflex actions of muscle stretch have been extensively studied, much less in known about the reflex actions of muscle contraction. In particular, there has been very little work on the neuronal mechanisms and functional role of reflex effects directed from the contracting muscle to other muscles. The purpose of the proposed research is to provide a quantitative analysis of these contractionevoked reflexes and to investigate their afferent and interneuronal mechanisms. This general goal can be divided into 3 specific aims: 1. To describe the pattern of reflex effects produced by muscle contraction in the decerebrate cat (with or without an additional partial spinal section). Reflex effects produced by isometric contractions (via ventral root stimulation), stretch, vibration and electrical stimulation of muscle nerves will be compared with the responses of different types of muscle afferents to determine the afferent source of these effects. 2. To describe the response of Group 1 and force activated interneurons to muscle contraction, stretch, vibration and nerve stimulation. Quantitative comparisons of reflex effects with afferent and interneuron response will be used to identify those interneurons most likely to mediate contractionevoked reflexes. 3. To determine the specific output connections of Group 1 and force activated interneurons by spiketriggered averaging from neuron discharge into electomyographic activity in various extensor muscles.

运动的瞬间控制取决于 对脊髓的下行命令和活动 脊髓反射通路。 虽然肌肉的反射动作 拉伸已被广泛研究，但人们知之甚少 肌肉伸展的反射作用已被广泛 对肌肉的反射作用进行了研究，但知之甚少 收缩。 特别是在这方面的工作还很少 反射效应的神经机制和功能作用 从收缩的肌肉引导到其他肌肉。 这 拟议研究的目的是提供定量的 分析这些收缩诱发的反射并调查 他们的传入和神经元间机制。 这个总体目标 具体目标可分为3个： 1. 描述肌肉产生的反射效应的模式 去大脑猫的收缩（有或没有额外的 部分脊柱切片）。 等距产生的反射效果 收缩（通过腹根刺激）、伸展、振动和 肌肉神经的电刺激将与 不同类型肌肉传入的反应以确定 这些效应的传入源。 2. 描述组 1 的响应和力激活 中间神经元负责肌肉收缩、伸展、振动和神经 刺激。 反射效果的定量比较 传入和中间神经元反应将用于识别那些 中间神经元最有可能介导收缩诱发的反射。 3.确定Group 1和Group 1的具体输出连接 通过尖峰触发平均来强制激活中间神经元 神经元放电到各种电子切除术活动中 伸肌。