LOCAL ANESTHETIC NEUROTOXICITY IN THE SPINAL CORD

局部麻醉剂对脊髓的神经毒性

基本信息

项目摘要

The administration of epidural doses of the local anesthetic NESACAINE-CE (2-chloroprocaine) was the common factor in recent reports of long-lasting neurological deficits following regional anesthesia. Subsequent reviews of the clinical literature as well as numerous experimental studies have failed to discriminate if nerve injury should be attributed to some or all local anesthetics, the NESACAINE antioxidant, or the inadvertent administration of large epidural doses into the spinal cord subarachnoid space. It is not possible to explain these inconsistencies in the absence of information about the mechanisms of the observed injury. Using a rat sciatic nerve model, the applicant has demonstrated that local anesthetic-induced peripheral nerve injury is mediated by an initial increase in permeability of the perineurial sheath, followed by decreased nerve blood flow, dilution of normally hypertonic endoneurial fluid, increased endoneurial fluid pressure, injury of Schwann cells, and nerve fiber injury. In spinal cord the possible interactions between altered permeability of barrier systems, injury-induced fluid accumulation, and changes in interstitial fluid chemistry have not been considered previously for any model of central nervous system toxicity; therefore, it is important that studies in the sciatic nerve be extended to test the hypothesis that spinal cord toxicity following local anesthetic administration is mediated by changes in the interstitial environment affecting both structure and function. Specifically, neurological injury might be secondary to alterations in protective barrier systems and a compromise of nutritive blood flow. Commercial local anesthetic preparations will first be tested using quantitative measures of electrophysiological function in order to determine the relative toxicity of the epidural and subarachnoid routes of administration. Nerve conduction velocity and refractory periods will be determined for both dorsal roots and microfilaments. Using this model of functional deficit, the toxicity of local anesthetics, drug vehicles, and injection volume will be tested. Subsequent experiments will provide functional and structural evidence for corresponding changes in nerve fibers, the dura mater barrier, spinal cord blood flow, and interstitial fluid. These experiments will quantify changes in barrier permeability (penetration of horseradish peroxidase), blood flow (measured with a diffusible tracer), endoneurial fluid electrolytes (visualized with energy dispersive x-ray spectrometry), and fluid pressure.
硬膜外给药局麻药NESACAINE-CE

项目成果

期刊论文数量(12)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Permeability and surface area of the blood-nerve barrier in galactose intoxication.
半乳糖中毒时血神经屏障的渗透性和表面积。
  • DOI:
    10.1016/0006-8993(93)90434-o
  • 发表时间:
    1993
  • 期刊:
  • 影响因子:
    2.9
  • 作者:
    Mizisin,AP;Kalichman,MW
  • 通讯作者:
    Kalichman,MW
Effects of cocaine on blood flow and prostaglandin metabolites in rat sciatic nerve.
可卡因对大鼠坐骨神经血流和前列腺素代谢的影响。
  • DOI:
    10.1152/ajpheart.1994.266.6.h2515
  • 发表时间:
    1994
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Kalichman,MW;Sanicolas,MT;Jorge,MC;Roux,L
  • 通讯作者:
    Roux,L
Physiologic Mechanisms by Which Local Anesthetics May Cause Injury to Nerve and Spinal Cord
局部麻醉药可能导致神经和脊髓损伤的生理机制
Quantitative histologic analysis of local anesthetic-induced injury to rat sciatic nerve.
局麻药所致大鼠坐骨神经损伤的定量组织学分析。
Effects of aging on nerve conduction block induced by bupivacaine and procaine in rats.
衰老对布比卡因和普鲁卡因引起的大鼠神经传导阻滞的影响。
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

MICHAEL W KALICHMAN其他文献

MICHAEL W KALICHMAN的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('MICHAEL W KALICHMAN', 18)}}的其他基金

Characterizing Privacy Perceptions and Risks in HIV Molecular Epidemiology
HIV 分子流行病学中的隐私认知和风险特征
  • 批准号:
    8789729
  • 财政年份:
    2014
  • 资助金额:
    $ 7.8万
  • 项目类别:
Standards of Scientific Conduct
科学行为标准
  • 批准号:
    7491756
  • 财政年份:
    2007
  • 资助金额:
    $ 7.8万
  • 项目类别:
Standards of Scientific Conduct
科学行为标准
  • 批准号:
    7288429
  • 财政年份:
    2007
  • 资助金额:
    $ 7.8万
  • 项目类别:
TRAINING IN CLINICAL RESEARCH ETHICS
临床研究伦理培训
  • 批准号:
    6923932
  • 财政年份:
    2001
  • 资助金额:
    $ 7.8万
  • 项目类别:
TRAINING IN CLINICAL RESEARCH ETHICS
临床研究伦理培训
  • 批准号:
    6532603
  • 财政年份:
    2001
  • 资助金额:
    $ 7.8万
  • 项目类别:
TRAINING IN CLINICAL RESEARCH ETHICS
临床研究伦理培训
  • 批准号:
    6615627
  • 财政年份:
    2001
  • 资助金额:
    $ 7.8万
  • 项目类别:
TRAINING IN CLINICAL RESEARCH ETHICS
临床研究伦理培训
  • 批准号:
    6286155
  • 财政年份:
    2001
  • 资助金额:
    $ 7.8万
  • 项目类别:
TRAINING IN CLINICAL RESEARCH ETHICS
临床研究伦理培训
  • 批准号:
    6775719
  • 财政年份:
    2001
  • 资助金额:
    $ 7.8万
  • 项目类别:
LOCAL ANESTHETIC NEUROTOXICITY IN THE SPINAL CORD
局部麻醉剂对脊髓的神经毒性
  • 批准号:
    3476889
  • 财政年份:
    1987
  • 资助金额:
    $ 7.8万
  • 项目类别:
LOCAL ANESTHETIC NEUROTOXICITY IN THE SPINAL CORD
局部麻醉剂对脊髓的神经毒性
  • 批准号:
    3476888
  • 财政年份:
    1987
  • 资助金额:
    $ 7.8万
  • 项目类别:

相似海外基金

New directions for x-ray spectrometry from portable to synchrotron science
X 射线光谱测定从便携式到同步加速器科学的新方向
  • 批准号:
    RGPIN-2018-03902
  • 财政年份:
    2022
  • 资助金额:
    $ 7.8万
  • 项目类别:
    Discovery Grants Program - Individual
New directions for x-ray spectrometry from portable to synchrotron science
X 射线光谱测定从便携式到同步加速器科学的新方向
  • 批准号:
    RGPIN-2018-03902
  • 财政年份:
    2021
  • 资助金额:
    $ 7.8万
  • 项目类别:
    Discovery Grants Program - Individual
New directions for x-ray spectrometry from portable to synchrotron science
X 射线光谱测定从便携式到同步加速器科学的新方向
  • 批准号:
    RGPIN-2018-03902
  • 财政年份:
    2020
  • 资助金额:
    $ 7.8万
  • 项目类别:
    Discovery Grants Program - Individual
New directions for x-ray spectrometry from portable to synchrotron science
X 射线光谱测定从便携式到同步加速器科学的新方向
  • 批准号:
    RGPIN-2018-03902
  • 财政年份:
    2019
  • 资助金额:
    $ 7.8万
  • 项目类别:
    Discovery Grants Program - Individual
New directions for x-ray spectrometry from portable to synchrotron science
X 射线光谱测定从便携式到同步加速器科学的新方向
  • 批准号:
    RGPIN-2018-03902
  • 财政年份:
    2018
  • 资助金额:
    $ 7.8万
  • 项目类别:
    Discovery Grants Program - Individual
Advances in x-ray spectrometry: new science through new sources
X 射线光谱测定的进展:新来源的新科学
  • 批准号:
    261523-2013
  • 财政年份:
    2017
  • 资助金额:
    $ 7.8万
  • 项目类别:
    Discovery Grants Program - Individual
Advances in x-ray spectrometry: new science through new sources
X 射线光谱测定的进展:新来源的新科学
  • 批准号:
    261523-2013
  • 财政年份:
    2016
  • 资助金额:
    $ 7.8万
  • 项目类别:
    Discovery Grants Program - Individual
Advances in x-ray spectrometry: new science through new sources
X 射线光谱测定的进展:新来源的新科学
  • 批准号:
    261523-2013
  • 财政年份:
    2015
  • 资助金额:
    $ 7.8万
  • 项目类别:
    Discovery Grants Program - Individual
Application of energy dispersive X-ray spectrometry (EDX) in forensic practice
能量色散 X 射线光谱 (EDX) 在法医学实践中的应用
  • 批准号:
    15K19273
  • 财政年份:
    2015
  • 资助金额:
    $ 7.8万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Advances in x-ray spectrometry: new science through new sources
X 射线光谱测定的进展:新来源的新科学
  • 批准号:
    261523-2013
  • 财政年份:
    2014
  • 资助金额:
    $ 7.8万
  • 项目类别:
    Discovery Grants Program - Individual
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了