OCULAR MOTOR AND NEUROANATOMIC STUDIES OF SCHIZOPHRENIA

精神分裂症的眼运动和神经解剖学研究

• 批准号: 3476100
• 负责人: BRETT A CLEMENTZ
• 金额: $ 5.96万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-01 至 1998-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3476100
• 关键词: behavioral genetics; cerebral dominance; eye movement disorders; family genetics; human subject; magnetic resonance imaging; mental disorder diagnosis; neuroanatomy; neurobiology; saccades; schizophrenia; smooth pursuit eye movement; vestibular pathway; vision tests; visual fixation; visual stimulus

Ocular motor abnormalities frequently occur among schizophrenics and their first-degree biological relatives. It also appears that some as yet unidentified aspect of ocular motor dysfunction is specific to schizophrenia among psychiatric patients. furthermore, the results of family studies suggest that ocular motor dysfunction may be a marker variable of genetic liability for this disorder. An important feature of ocular motor functioning as a potential marker variable of liability for schizophrenia is knowledge of its neural circuitry. Particular patterns of ocular motor response are associated with pathology in particular brain regions. Identifying ocular motor abnormalities that are specific to schizophrenics (among psychiatric patients) and their first-degree biological relatives could serve two functions simultaneously: (1) clarification of schizophrenia's neuropathology, and (2) providing a sensitive liability indicator which could be a useful adjunct to clinical diagnoses in subsequent linkage studies. The main purposes of the present project are to (1) identify schizophrenia- specific ocular motor abnormalities using neuro-ophthalmological measurement techniques; (2) clarify the relationship between ocular motor abnormalities and structural brain abnormalities observed among schizophrenics; and (3) identify those specific ocular motor abnormalities which also occur with high frequency among schizophrenics' first-degree biological relatives. Measures of visual fixation, smooth pursuit, and saccadic performance will be obtained from schizophrenic, affective disordered, and non-psychiatric comparison subjects. We will first investigate basic issues concerning which brain areas (vestibulocerebellum, brainstem, cortical and subcortical hemispheric structures) could be involved in schizophrenics' ocular motor dysfunction. The pattern of observed abnormalities will be fully characterized, and we will determine which measures maximally distinguish schizophrenics from other subjects. Those ocular motor abnormalities which are specific to schizophrenia will be correlated with quantified magnetic resonance images to evaluate the relationship between functional and structural measures of neuropathology among such patients. We will also attempt to determine whether these ocular motor abnormalities may be a consequence of having the disease or are associated with a neurobiological predisposition for this illness by studying schizophrenics' first-degree biological relatives. Research projects such as this may be necessary to help clarify the neuropathology and genetics of schizophrenia.

眼球运动异常经常发生在精神分裂症患者中， 他们的一级血亲 也有人认为，作为 然而，眼运动功能障碍的未确定方面是特定于 精神分裂症患者中。 此外， 家族研究表明，眼运动功能障碍可能是一个标志， 这种疾病的遗传易感性的变量。 一个重要特征 眼运动功能作为一个潜在的标志变量的责任 就是了解精神分裂症的神经回路 特别 眼运动反应的模式与以下疾病的病理学相关： 特定的大脑区域。 识别眼部运动异常， 是精神分裂症患者（精神病患者）特有的， 一级血亲有两个功能 同时：（1）阐明精神分裂症的神经病理学， (2)提供一个敏感的负债指标， 在随后的连锁研究中辅助临床诊断。 主要 本项目的目的是（1）识别精神分裂症- 使用神经眼科学的特异性眼运动异常 测量技术;（2）阐明眼运动与眼运动之间的关系 异常和大脑结构异常， 精神分裂症;（3）识别那些特定的眼运动 在精神分裂症患者中， 一级血亲 视觉注视测量，平滑 追求，和扫视性能将从精神分裂症， 情感障碍和非精神病对照受试者。 我们将 首先研究关于哪些大脑区域 （前庭小脑、脑干、皮质和皮质下半球） 结构）可能参与精神分裂症患者的眼球运动 功能障碍 观察到的异常模式将完全 特征，我们将确定哪些措施最大限度地区分 精神分裂症患者 那些眼部运动异常 精神分裂症的特异性， 磁共振成像，以评估功能之间的关系， 和神经病理学的结构测量。 我们将 还试图确定这些眼运动异常是否可以 是患有疾病的后果或与 神经生物学倾向，通过研究 精神分裂症患者的一级血亲 研究项目 例如，这可能是必要的，以帮助澄清神经病理学， 精神分裂症的遗传学