NEURAL SUBSTRATES OF LEARNING AND MEMORY

学习和记忆的神经基质

• 批准号: 3477202
• 负责人: TIM P TULLY
• 金额: $ 8.13万
• 依托单位: BRANDEIS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-02-01 至 1993-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3477202
• 关键词: Drosophilidae; adenylate cyclase; association learning; biological models; brain mapping; learning; membrane channels; memory; metamorphosis; molecular psychobiology; mutant

Biochemical analyses of Drosophila single-gene mutants, isolated for their effects on associative learning and memory, have implicated the monoamine-stimulated adenylate cyclase pathway. Behavioral analyses of other mutations isolated for their effects on specific biochemical or physiological systems will broaden our understanding of the biological mechanisms underlying associative learning and memory. Of particular interest are mutations affecting biogenic amine metabolism or neuronal ion channels, since they provide empirical tests of a current model of associative learning. Long-term memory formation will be studied in memory consolidation experiments and by assessing the stability of memory through metamorphosis in normal and mutant flies. A study of memory through metamorphosis in mutants with degenerated brain structures may identify specific anatomical sites involved with long-term memory storage or retrievel. Anatomical sites involved with associative learning also will be identified by generating flies mosaic for normal and mutant tissue. Behavioral analyses of learning or memory in these mosaics may reveal the existence of "learning foci" in the brain.

果蝇单基因突变体的生化分析，分离 因为它们对关联学习和记忆的影响 暗示单胺刺激的腺苷酸环化酶途径。 针对其影响的其他突变的行为分析 在特定的生化或生理系统上，将扩大我们的 了解关联的生物学机制 学习和记忆。 特别感兴趣的是突变 影响生物胺代谢或神经离子通道， 由于它们提供了当前模型的经验测试 协会学习。 长期记忆形成将是 在记忆巩固实验中进行了研究，并通过评估 通过正常和突变体中的变形来使记忆的稳定性 苍蝇。 通过在具有变形的突变体中对记忆的研究 退化的大脑结构可能识别特定的解剖学 与长期存储器存储或retrievel有关的站点。 参与关联学习的解剖站点也将是 通过生成正常和突变体的果蝇鉴定 组织。 在这些中学习或记忆的行为分析 马赛克可能会揭示大脑中“学习焦点”的存在。